1750 in literature
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The year 1750 in literature involved some significant events and new books.
- March - The Rambler is founded by Edward Cave; it lasts for 208 issues, and is mostly written by Samuel Johnson.
- Weekly meetings for contributors to the Encyclopédie begin, at the salon of Baron d'Holbach.
- Jean-Jacques Rousseau wins the prize of the Academy of Dijon for his Discourse on the Arts and Sciences.
- The London theatres wage "the Romeo and Juliet war" — competing productions with David Garrick and Anne Bellamy at the Theatre Royal, Drury Lane versus Spranger Barry and Susannah Cibber at the Royal Opera House in Covent Garden.
- Old Orchard Street Theatre opens in Bath (England) under the management of John Palmer, with a performance of Shakespeare’s Henry IV, Part 2.
- Carlo Goldoni commits himself to writing a comedy for each week of the 1750–51 seasons at Gerolamo Medebach's Teatro San Angelo in Venice – 16 plays.
- After taking his MD at Aberdeen, Tobias Smollett travels in France, collecting material for The Adventures of Peregrine Pickle.
- The Adventures of Mr. Loveill, interspers'd with many real amours of the modern polite world
- The Nominal Husband, or, Distress'd Innocence
- Revived Fugitive: a novel, translated from the French
- Henry Brooke - A New Collection of Fairy Tales
- John Cleland - Fanny Hill (official and expurgated)
- Sarah Fielding (attr.) - The History of Charlotte Summers
- Edward Kimber - The Life and Adventures of Joe Thompson
- Charlotte Lennox - The Life of Harriot Stuart
- Robert Paltock - The Life and Adventures of Peter Wilkins
- Sarah Scott - The History of Cornelia
- Kitty Clive - The Rehearsal, or, Bays in Petticoats
- Carlo Goldoni
- Agustín Montiano y Luyando - Virginia
- William Shirley - Edward the Black Prince
- Voltaire - Oreste
- William Whitehead - The Roman Father
- William Collins - The Passions
- Thomas Cooke - An Ode on Martial Virtue
- Robert Dodsley - The Oeconomy of Human Life
- Mary Jones - Miscellanies
- Thomas Warton - The Triumph of Isis
- Edward Young - The Complaint (aka Night Thoughts)
- William Blackstone - An Essay on Collateral Consanguinity
- John Campbell - The Present State of Europe
- Zachary Grey - A Free and Familiar Letter to William Warburton
- Eliza Haywood - A Present for Women Addicted to Drinking (on the Gin crisis)
- Francis Hutcheson - Reflections Upon Laughter (philosophy of humor)
- Agustín Montiano y Luyando - Discurso sobre las tragedias españolas
- Laurence Sterne - The Abuses of Conscience
- Madeleine de Puisieux - La Femme n’est pas inférieure à l'homme (Woman is not inferior to man)
- January 7 – Robert Anderson, Scottish critic (died 1803)
- June 13 – James Burney, English rear-admiral and naval writer (died 1821)
- September 5 – Robert Fergusson, Scottish poet writing in Braid Scots (died 1774)
- Unknown date – Henrietta Maria Bowdler, English author and expurgator (died 1830)
- February – Aaron Hill, English dramatist (born 1685)
- June 15 – Marguerite De Launay, Baronne Staal, French writer (born 1684)
- November 11 – Apostolo Zeno, Venetian poet and journalist (born 1668)
- November 18 – Susanna Highmore, English poet (born 1690)