2-methyleneglutarate mutase

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2-methyleneglutarate mutase
EC number5.4.99.4
CAS number9059-10-3
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a 2-methyleneglutarate mutase (EC is an enzyme that catalyzes the chemical reaction

2-methyleneglutarate 2-methylene-3-methylsuccinate

Hence, this enzyme has one substrate, 2-methyleneglutarate, and one product, 2-methylene-3-methylsuccinate.

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. The systematic name of this enzyme class is 2-methyleneglutarate carboxy-methylenemethylmutase. This enzyme is also called alpha-methyleneglutarate mutase. This enzyme participates in c5-branched dibasic acid metabolism. It employs one cofactor, cobamide.


  • Kung HF, Cederbaum S, Tsai L, Stadtman TC (1970). "Nicotinic acid metabolism. V. A cobamide coenzyme-dependent conversion of alpha-methyleneglutaric acid to dimethylmaleic acid". Proc. Natl. Acad. Sci. U.S.A. 65 (4): 978–84. doi:10.1073/pnas.65.4.978. PMC 283012. PMID 5266166.
  • Kung HF, Stadtman TC (1971). "Nicotinic acid metabolism. VI. Purification and properties of alpha-methyleneglutarate mutase (B 12-dependent) and methylitaconate isomerase". J. Biol. Chem. 246 (10): 3378–88. PMID 5574401.