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2-methylisocitrate dehydratase

From Wikipedia, the free encyclopedia
2-methylisocitrate dehydratase
Identifiers
EC no.4.2.1.99
CAS no.170780-51-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

The enzyme 2-methylisocitrate dehydratase (EC 4.2.1.99) catalyzes the chemical reaction

(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate (Z)-but-2-ene-1,2,3-tricarboxylate + H2O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]. This enzyme is also called (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase. This enzyme participates in propanoate metabolism.

References

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  • Aoki H, Uchiyama H, Umetsu H, Tabuchi T (1995). "Isolation of 2-methylisocitrate dehydratase, a new enzyme serving in the methylcitric acid cycle for propionate metabolism, from Yarrowia lipolytica". Biosci. Biotechnol. Biochem. 59 (10): 1825–1828. doi:10.1271/bbb.59.1825.
  • Tabuchi T, Umetsu H, Aoki H, Uchiyama H (1995). "Characteristics of 2-methylisocitrate dehydratase, isolated from Yarrowia lipolytica, in comparison to aconitase". Biosci. Biotechnol. Biochem. 59 (11): 2013–2017. doi:10.1271/bbb.59.2013.