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23S rRNA pseudouridine2604 synthase

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23S rRNA pseudouridine2604 synthase
Identifiers
EC no.5.4.99.21
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins

23S rRNA pseudouridine2604 synthase (EC 5.4.99.21, RluF, YjbC) is an enzyme with systematic name 23S rRNA-uridine2604 uracil mutase.[1][2][3] This enzyme catalyses the following chemical reaction

23S rRNA uridine2604 23S rRNA pseudouridine2604

The enzyme can, to a small extent, also react with uridine2605.

References

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  1. ^ Del Campo M, Kaya Y, Ofengand J (November 2001). "Identification and site of action of the remaining four putative pseudouridine synthases in Escherichia coli". RNA. 7 (11): 1603–15. PMC 1370202. PMID 11720289.
  2. ^ Alian A, DeGiovanni A, Griner SL, Finer-Moore JS, Stroud RM (May 2009). "Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U2604 of the ribosome". Journal of Molecular Biology. 388 (4): 785–800. doi:10.1016/j.jmb.2009.03.029. PMC 2796871. PMID 19298824.
  3. ^ Sunita S, Zhenxing H, Swaathi J, Cygler M, Matte A, Sivaraman J (June 2006). "Domain organization and crystal structure of the catalytic domain of E.coli RluF, a pseudouridine synthase that acts on 23S rRNA". Journal of Molecular Biology. 359 (4): 998–1009. doi:10.1016/j.jmb.2006.04.019. PMID 16712869.
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