3-Aminopyridine

3-Aminopyridine
Names
	IUPAC name Pyridin-3-amine
	Other names 3-Pyridinamine; 3-Pyridylamine
Identifiers
CAS Number	462-08-8 ;
3D model (JSmol)	Interactive image;
ChemSpider	9615 ;
ECHA InfoCard	100.006.658
PubChem CID	10009;
CompTox Dashboard (EPA)	DTXSID9047461 ;
	SMILES C1=CC(=CN=C1)N;
Properties
Chemical formula	C5H6N2
Molar mass	94.117 g·mol−1
Appearance	Dull brown crystals
Melting point	65 °C (149 °F; 338 K)
Boiling point	248 °C (478 °F; 521 K)
Solubility in water	Soluble[vague]
Solubility in alcohol and benzene	Soluble[vague]
Hazards
Flash point	124 °C (255 °F; 397 K)
Autoignition; temperature	628 °C (1,162 °F; 901 K)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

3-Aminopyridine is an aminopyridine. It can be used in the synthesis of organic ligand 3-pyridylnicotinamide

Preparation

3-Aminopyridine can be prepared by heating nicotinamide with sodium hypobromite which is in turn prepared in situ by the reaction of sodium hydroxide and bromine at 70 °C.^[1]

Toxicology

3-Aminopyridine can easily be absorbed through the skin. It is fatal if swallowed or absorbed through the skin. High concentrations can be extremely destructive to the tissues of mucous membranes and upper respiratory tract eyes and skin. Symptoms may also include convulsions and death. It also causes damage to the nervous system. Thermal decomposition leads to evolution of toxic gases such as carbon monoxide and oxides of nitrogen.

References

^ C. F. H. Allen and Calvin N. Wolf (1950). "3-Aminopyridine". Organic Syntheses. 30: 3; Collected Volumes, vol. 4, p. 45.

[1] C. F. H. Allen and Calvin N. Wolf (1950). "3-Aminopyridine". Organic Syntheses. 30: 3; Collected Volumes, vol. 4, p. 45.

[1]