3-hydroxybutyryl-CoA epimerase

From Wikipedia, the free encyclopedia
Jump to: navigation, search
3-hydroxybutyryl-CoA epimerase
EC number
CAS number 9024-21-9
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a 3-hydroxybutyryl-CoA epimerase (EC is an enzyme that catalyzes the chemical reaction

(S)-3-hydroxybutanoyl-CoA (R)-3-hydroxybutanoyl-CoA

Hence, this enzyme has one substrate, (S)-3-hydroxybutanoyl-CoA, and one product, (R)-3-hydroxybutanoyl-CoA.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on hydroxy acids and derivatives. The systematic name of this enzyme class is 3-hydroxybutanoyl-CoA 3-epimerase. Other names in common use include 3-hydroxybutyryl coenzyme A epimerase, and 3-hydroxyacyl-CoA epimerase. This enzyme participates in fatty acid metabolism and butanoate metabolism.

Structural studies[edit]

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1WDK, 1WDL, 1WDM, and 2D3T.


  • Stern JR, del Campillo A, Lehninger AL (1955). "Enzymatic racemization of beta-hydroxybutyryl-S-CoA and the stereospecificity of enzymes of the fatty acid cycle". J. Am. Chem. Soc. 77 (4): 1073–1074. doi:10.1021/ja01609a105. 
  • Wakil SJ (1955). "D(-)beta-Hydroxybutyryl CoA dehydrogenase". Biochim. Biophys. Acta. 18 (2): 314–315. doi:10.1016/0006-3002(55)90089-5. PMID 13276396.