4-hydroxyproline epimerase

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4-hydroxyproline epimerase
Identifiers
EC number 5.1.1.8
CAS number 9024-23-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a 4-hydroxyproline epimerase (EC 5.1.1.8) is an enzyme that catalyzes the chemical reaction

trans-4-hydroxy-L-proline cis-4-hydroxy-D-proline

Hence, this enzyme has one substrate, trans-4-hydroxy-L-proline, and one product, cis-4-hydroxy-D-proline.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on amino acids and derivatives. The systematic name of this enzyme class is 4-hydroxyproline 2-epimerase. Other names in common use include hydroxyproline epimerase, hydroxyproline 2-epimerase, and L-hydroxyproline epimerase. This enzyme participates in arginine and proline metabolism.

References[edit]

  • Adams E; Norton IL (1964). "Purification and properties of inducible hydroxyproline 2-epimerase from Pseudomonas". J. Biol. Chem. 239: 1525–1535. PMID 14189888.