In enzymology, a 4-hydroxyproline epimerase (EC 18.104.22.168) is an enzyme that catalyzes the chemical reaction
- trans-4-hydroxy-L-proline cis-4-hydroxy-D-proline
Hence, this enzyme has one substrate, trans-4-hydroxy-L-proline, and one product, cis-4-hydroxy-D-proline.
This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on amino acids and derivatives. The systematic name of this enzyme class is 4-hydroxyproline 2-epimerase. Other names in common use include hydroxyproline epimerase, hydroxyproline 2-epimerase, and L-hydroxyproline epimerase. This enzyme participates in arginine and proline metabolism.
- Adams E; Norton IL (1964). "Purification and properties of inducible hydroxyproline 2-epimerase from Pseudomonas". J. Biol. Chem. 239: 1525–1535. PMID 14189888.