From Wikipedia, the free encyclopedia
U6 snRNA-associated Sm-like protein LSm7 is a protein that in humans is encoded by the LSM7 gene .[5] [6] [7]
Function
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM][7]
Interactions
LSM7 has been shown to interact with TACC1 [8] [9] and LSM2 .[10] [11]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000130332 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035215 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Lührmann R (Oct 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro" . The EMBO Journal . 18 (20): 5789–802. doi :10.1093/emboj/18.20.5789 . PMC 1171645 . PMID 10523320 .
^ Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T (Dec 2002). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci" . RNA . 8 (12): 1489–501. doi :10.1017/S1355838202021726 (inactive 2021-01-11). PMC 1370355 . PMID 12515382 . {{cite journal }}
: CS1 maint: DOI inactive as of January 2021 (link )
^ a b "Entrez Gene: LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)" .
^ Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (Nov 2003). "TACC1-chTOG-Aurora A protein complex in breast cancer" . Oncogene . 22 (50): 8102–16. doi :10.1038/sj.onc.1206972 . PMID 14603251 .
^ Conte N, Charafe-Jauffret E, Delaval B, Adélaïde J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D (Aug 2002). "Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators" . Oncogene . 21 (36): 5619–30. doi :10.1038/sj.onc.1205658 . PMID 12165861 .
^ Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation" . Genome Research . 14 (7): 1315–23. doi :10.1101/gr.2122004 . PMC 442147 . PMID 15231747 .
^ Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics . 83 (1): 153–67. doi :10.1016/S0888-7543(03)00235-0 . PMID 14667819 .
Further reading
Friesen WJ, Dreyfuss G (Aug 2000). "Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN)" . The Journal of Biological Chemistry . 275 (34): 26370–5. doi :10.1074/jbc.M003299200 . PMID 10851237 .
Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (Oct 2001). "Protein-protein interaction panel using mouse full-length cDNAs" . Genome Research . 11 (10): 1758–65. doi :10.1101/gr.180101 . PMC 311163 . PMID 11591653 .
Eystathioy T, Peebles CL, Hamel JC, Vaughn JH, Chan EK (Mar 2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera" . Arthritis and Rheumatism . 46 (3): 726–34. doi :10.1002/art.10220 . PMID 11920408 .
Conte N, Charafe-Jauffret E, Delaval B, Adélaïde J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D (Aug 2002). "Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators" . Oncogene . 21 (36): 5619–30. doi :10.1038/sj.onc.1205658 . PMID 12165861 .
Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (Nov 2003). "TACC1-chTOG-Aurora A protein complex in breast cancer" . Oncogene . 22 (50): 8102–16. doi :10.1038/sj.onc.1206972 . PMID 14603251 .
Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics . 83 (1): 153–67. doi :10.1016/S0888-7543(03)00235-0 . PMID 14667819 .
Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation" . Genome Research . 14 (7): 1315–23. doi :10.1101/gr.2122004 . PMC 442147 . PMID 15231747 .
Stanĕk D, Neugebauer KM (Sep 2004). "Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer" . The Journal of Cell Biology . 166 (7): 1015–25. doi :10.1083/jcb.200405160 . PMC 2172029 . PMID 15452143 .