TACC1

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TACC1
Identifiers
Aliases TACC1, Ga55, transforming acidic coiled-coil containing protein 1
External IDs MGI: 2443510 HomoloGene: 4575 GeneCards: TACC1
RNA expression pattern
PBB GE TACC1 217437 s at fs.png

PBB GE TACC1 200911 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001122824
NM_001146216
NM_006283
NM_001330521

NM_177089
NM_199323

RefSeq (protein)

NP_001116296
NP_001139688
NP_001317450
NP_006274

NP_796063.3
NP_955355.1
NP_796063
NP_955355

Location (UCSC) Chr 8: 38.73 – 38.85 Mb Chr 8: 25.15 – 25.26 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Transforming acidic coiled-coil-containing protein 1 is a protein that in humans is encoded by the TACC1 gene.[3]

Function[edit]

The function of this gene has not yet been determined; however, it is speculated that it may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers.[3]

Interactions[edit]

TACC1 has been shown to interact with:

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: TACC1 transforming, acidic coiled-coil containing protein 1". 
  4. ^ a b Delaval B, Ferrand A, Conte N, Larroque C, Hernandez-Verdun D, Prigent C, Birnbaum D (Jun 2004). "Aurora B -TACC1 protein complex in cytokinesis". Oncogene. 23 (26): 4516–22. doi:10.1038/sj.onc.1207593. PMID 15064709. 
  5. ^ a b c d Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (Nov 2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID 14603251. 
  6. ^ Ryser S, Dizin E, Jefford CE, Delaval B, Gagos S, Christodoulidou A, Krause KH, Birnbaum D, Irminger-Finger I (Feb 2009). "Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora B degradation, cancer-associated BARD1beta scaffolds Aurora B and BRCA2". Cancer Res. 69 (3): 1125–34. doi:10.1158/0008-5472.CAN-08-2134. PMID 19176389. 
  7. ^ Lauffart B, Howell SJ, Tasch JE, Cowell JK, Still IH (Apr 2002). "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells". Biochem. J. 363 (Pt 1): 195–200. doi:10.1042/0264-6021:3630195. PMC 1222467Freely accessible. PMID 11903063. 
  8. ^ a b Conte N, Charafe-Jauffret E, Delaval B, Adélaïde J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D (Aug 2002). "Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators". Oncogene. 21 (36): 5619–30. doi:10.1038/sj.onc.1205658. PMID 12165861. 

Further reading[edit]