CLK2

CLK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3NR9
Identifiers
Aliases	CLK2, CDC like kinase 2
External IDs	OMIM: 602989; MGI: 1098669; HomoloGene: 33303; GeneCards: CLK2; OMA:CLK2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q22 Start 155,262,868 bp End 155,278,491 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 F1 Start 89,072,102 bp End 89,084,228 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube right lobe of thyroid gland pituitary gland spleen right adrenal cortex left lobe of thyroid gland anterior pituitary right ovary left ovary left adrenal cortex Top expressed in genital tubercle tail of embryo zygote secondary oocyte neural layer of retina condyle fossa epiblast ventricular zone granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding kinase activity protein serine/threonine kinase activity protein kinase activity protein serine/threonine/tyrosine kinase activity ATP binding nucleotide binding protein tyrosine kinase activity transferase activity identical protein binding Cellular component nucleoplasm nucleus nuclear speck nuclear body Biological process negative regulation of gluconeogenesis regulation of RNA splicing phosphorylation protein phosphorylation protein autophosphorylation response to organic substance response to ionizing radiation peptidyl-tyrosine phosphorylation response to retinoic acid Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1196 12748 Ensembl ENSG00000261893 ENSG00000176444 ENSMUSG00000068917 UniProt P49760 O35491 RefSeq (mRNA) NM_001291 NM_001294338 NM_001294339 NM_003993 NM_001363704 NM_001163432 NM_007712 RefSeq (protein) NP_001281267 NP_001281268 NP_003984 NP_001350633 NP_001156904 NP_031738 Location (UCSC) Chr 1: 155.26 – 155.28 Mb Chr 3: 89.07 – 89.08 Mb PubMed search
Wikidata
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Dual specificity protein kinase CLK2 is an enzyme that in humans is encoded by the CLK2 gene.

Function

This gene encodes a member of the CLK family of dual specificity protein kinases. CLK family members have shown to interact with, and phosphorylate, serine/arginine-rich (SR) proteins of the spliceosomal complex, which is a part of the regulatory mechanism that enables the SR proteins to control RNA splicing. This protein kinase is involved in the regulation of several cellular processes and may serve as a link between cell cycle progression, apoptosis, and telomere length regulation.

External links

• Human CLK2 genome location and CLK2 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: P49760 (Dual specificity protein kinase CLK2) at the PDBe-KB.

Further reading

• Lee K, Du C, Horn M, Rabinow L (Nov 1996). "Activity and autophosphorylation of LAMMER protein kinases". The Journal of Biological Chemistry. 271 (44): 27299–303. doi:10.1074/jbc.271.44.27299. PMID 8910305.
• Winfield SL, Tayebi N, Martin BM, Ginns EI, Sidransky E (Oct 1997). "Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease". Genome Research. 7 (10): 1020–6. doi:10.1101/gr.7.10.1020. PMC 310674. PMID 9331372.
• Duncan PI, Stojdl DF, Marius RM, Scheit KH, Bell JC (Jun 1998). "The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing". Experimental Cell Research. 241 (2): 300–8. doi:10.1006/excr.1998.4083. PMID 9637771.
• Tsujikawa M, Kurahashi H, Tanaka T, Okada M, Yamamoto S, Maeda N, Watanabe H, Inoue Y, Kiridoshi A, Matsumoto K, Ohashi Y, Kinoshita S, Shimomura Y, Nakamura Y, Tano Y (Oct 1998). "Homozygosity mapping of a gene responsible for gelatinous drop-like corneal dystrophy to chromosome 1p". American Journal of Human Genetics. 63 (4): 1073–7. doi:10.1086/302071. PMC 1377503. PMID 9758629.
• Nayler O, Schnorrer F, Stamm S, Ullrich A (Dec 1998). "The cellular localization of the murine serine/arginine-rich protein kinase CLK2 is regulated by serine 141 autophosphorylation". The Journal of Biological Chemistry. 273 (51): 34341–8. doi:10.1074/jbc.273.51.34341. PMID 9852100.
• Moeslein FM, Myers MP, Landreth GE (Sep 1999). "The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B". The Journal of Biological Chemistry. 274 (38): 26697–704. doi:10.1074/jbc.274.38.26697. PMID 10480872.
• Nothwang HG, Kim HG, Aoki J, Geisterfer M, Kübart S, Wegner RD, van Moers A, Ashworth LK, Haaf T, Bell J, Arai H, Tommerup N, Ropers HH, Wirth J (Apr 2001). "Functional hemizygosity of PAFAH1B3 due to a PAFAH1B3-CLK2 fusion gene in a female with mental retardation, ataxia and atrophy of the brain". Human Molecular Genetics. 10 (8): 797–806. doi:10.1093/hmg/10.8.797. PMID 11285245.
• Ravichandran LV, Chen H, Li Y, Quon MJ (Oct 2001). "Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor". Molecular Endocrinology. 15 (10): 1768–80. doi:10.1210/mend.15.10.0711. PMID 11579209.
• Jiang N, Bénard CY, Kébir H, Shoubridge EA, Hekimi S (Jun 2003). "Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation". The Journal of Biological Chemistry. 278 (24): 21678–84. doi:10.1074/jbc.M300286200. PMID 12670948.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biology. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization" (PDF). Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Collis SJ, Barber LJ, Clark AJ, Martin JS, Ward JD, Boulton SJ (Apr 2007). "HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability". Nature Cell Biology. 9 (4): 391–401. doi:10.1038/ncb1555. PMID 17384638. S2CID 544104.