RGS18

RGS18
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DLV, 2JM5, 2OWI
Identifiers
Aliases	RGS18, RGS13, regulator of G-protein signaling 18, regulator of G protein signaling 18
External IDs	OMIM: 607192; MGI: 1927498; HomoloGene: 11281; GeneCards: RGS18; OMA:RGS18 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q31.2 Start 192,158,462 bp End 192,185,815 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 F|1 62.99 cM Start 144,628,421 bp End 144,651,173 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte blood trabecular bone bone marrow bone marrow cells appendix spleen right lung testicle Top expressed in granulocyte blood tibiofemoral joint dermis spleen bone marrow body of femur lumbar spinal ganglion stroma of bone marrow abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase activator activity protein binding GTPase activity Cellular component cytoplasm plasma membrane Biological process G protein-coupled receptor signaling pathway positive regulation of GTPase activity negative regulation of signal transduction regulation of G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64407 64214 Ensembl ENSG00000150681 ENSMUSG00000026357 UniProt Q9NS28 Q99PG4 RefSeq (mRNA) NM_130782 NM_022881 RefSeq (protein) NP_570138 NP_075019 Location (UCSC) Chr 1: 192.16 – 192.19 Mb Chr 1: 144.63 – 144.65 Mb PubMed search
Wikidata
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Regulator of G-protein signaling 18 is a protein that in humans is encoded by the RGS18 gene.

Function

This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Interactions

RGS18 has been shown to interact with GNAI3.

Further reading

• Nagata Y, Oda M, Nakata H, Shozaki Y, Kozasa T, Todokoro K (May 2001). "A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes". Blood. 97 (10): 3051–60. doi:10.1182/blood.V97.10.3051. PMID 11342430.
• Yowe D, Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, Yu K, Faron L, Shen M, Cleary J, Wilkie TM, Gutierrez-Ramos C, Hodge MR (Oct 2001). "RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes". The Biochemical Journal. 359 (Pt 1): 109–18. doi:10.1042/bj3590109. PMC 1222126. PMID 11563974.
• Sierra DA, Gilbert DJ, Householder D, Grishin NV, Yu K, Ukidwe P, Barker SA, He W, Wensel TG, Otero G, Brown G, Copeland NG, Jenkins NA, Wilkie TM (Feb 2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID 11829488.
• Gagnon AW, Murray DL, Leadley RJ (Jul 2002). "Cloning and characterization of a novel regulator of G protein signalling in human platelets". Cellular Signalling. 14 (7): 595–606. doi:10.1016/S0898-6568(02)00012-8. PMID 11955952.
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Larminie C, Murdock P, Walhin JP, Duckworth M, Blumer KJ, Scheideler MA, Garnier M (Mar 2004). "Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system". Brain Research. Molecular Brain Research. 122 (1): 24–34. doi:10.1016/j.molbrainres.2003.11.014. PMID 14992813.
• Aldenhoven J, Chen Y, Moran C (2006). "Assignment of UCK2, ATF3 and RGS18 from human chromosome 1 to porcine chromosomes 4, 9 and 10 with somatic and radiation hybrid panels". Cytogenetic and Genome Research. 112 (3–4): 341F. doi:10.1159/000089896. PMID 16484797.