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RGS18

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RGS18
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRGS18, RGS13, regulator of G-protein signaling 18, regulator of G protein signaling 18
External IDsOMIM: 607192; MGI: 1927498; HomoloGene: 11281; GeneCards: RGS18; OMA:RGS18 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_130782

NM_022881

RefSeq (protein)

NP_570138

NP_075019

Location (UCSC)Chr 1: 192.16 – 192.19 MbChr 1: 144.63 – 144.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Regulator of G-protein signaling 18 is a protein that in humans is encoded by the RGS18 gene.[5][6]

Function

This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[6]

Interactions

RGS18 has been shown to interact with GNAI3.[7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000150681Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026357Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Park IK, Klug CA, Li K, Jerabek L, Li L, Nanamori M, Neubig RR, Hood L, Weissman IL, Clarke MF (Jan 2001). "Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells". The Journal of Biological Chemistry. 276 (2): 915–23. doi:10.1074/jbc.M005947200. PMID 11042171.
  6. ^ a b "Entrez Gene: RGS18 regulator of G-protein signalling 18".
  7. ^ Yowe D, Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, Yu K, Faron L, Shen M, Cleary J, Wilkie TM, Gutierrez-Ramos C, Hodge MR (Oct 2001). "RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes". The Biochemical Journal. 359 (Pt 1): 109–18. doi:10.1042/bj3590109. PMC 1222126. PMID 11563974.
  8. ^ Gagnon AW, Murray DL, Leadley RJ (Jul 2002). "Cloning and characterization of a novel regulator of G protein signalling in human platelets". Cellular Signalling. 14 (7): 595–606. doi:10.1016/S0898-6568(02)00012-8. PMID 11955952.

Further reading