ITPKB

ITPKB
Identifiers
Aliases	ITPKB, IP3-3KB, IP3K, IP3K-B, IP3KB, PIG37, inositol-trisphosphate 3-kinase B
External IDs	OMIM: 147522; MGI: 109235; HomoloGene: 1672; GeneCards: ITPKB; OMA:ITPKB - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	226,739,323 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	180,252,367 bp
RNA expression pattern
	Top expressed in
	external globus pallidus; ; pars reticulata; ; dorsal motor nucleus of vagus nerve; ; internal globus pallidus; ; inferior olivary nucleus; ; pars compacta; ; subthalamic nucleus; ; ventral tegmental area; ; superior vestibular nucleus; ; middle frontal gyrus;
	Top expressed in
	choroid plexus of fourth ventricle; ; lactiferous gland; ; sciatic nerve; ; islet of Langerhans; ; right lung; ; internal carotid artery; ; blood; ; thymus; ; left lung; ; right lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; calmodulin binding; kinase activity; protein binding; ATP binding; inositol-1,4,5-trisphosphate 3-kinase activity;
Cellular component	cytosol; membrane; nucleus;
Biological process	regulation of protein phosphorylation; cellular response to calcium ion; negative regulation of neutrophil apoptotic process; phosphorylation; common myeloid progenitor cell proliferation; myeloid cell homeostasis; positive regulation of Ras protein signal transduction; inositol phosphate metabolic process; inositol trisphosphate metabolic process; MAPK cascade; cell surface receptor signaling pathway; T cell differentiation; positive thymic T cell selection; negative regulation of myeloid cell differentiation; positive regulation of alpha-beta T cell differentiation; thymic T cell selection; signal transduction; inositol phosphate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	3707
	320404
	ENSG00000143772
	ENSMUSG00000038855
	P27987
	B2RXC2
	NM_002221; NM_001388404
	NM_001081175
	NP_002212
	NP_001074644
	Wikidata
View/Edit Human	View/Edit Mouse

Inositol-trisphosphate 3-kinase B is an enzyme that in humans is encoded by the ITPKB gene.^[5]^[6]

Function

The protein encoded by the ITPKB gene is one of 3 isoforms of Inositol-trisphosphate 3-kinase expressed in humans. ITPKB protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate, which releases calcium from intracellular store in the endoplasmic reticulum by gating the inositol trisphosphate receptor. ITPKB produces Ins(1,3,4,5)P4, which does not gate the inositol trisphosphate receptor. The enzyme specifically phosphorylates the 1,4,5 isomer of IP3. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity.^[7] Itpkb regulates immune cell function and is required for T and B cell development.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143772 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038855 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Takazawa K, Perret J, Dumont JE, Erneux C (Oct 1991). "Molecular cloning and expression of a new putative inositol 1,4,5-trisphosphate 3-kinase isoenzyme". Biochem J. 278 (3): 883–6. doi:10.1042/bj2780883. PMC 1151429. PMID 1654894.
^ Erneux C, Roeckel N, Takazawa K, Mailleux P, Vassart G, Mattei MG (Dec 1992). "Localization of the genes for human inositol 1,4,5-trisphosphate 3-kinase A (ITPKA) and B (ITPKB) to chromosome regions 15q14-q21 and 1q41-q43, respectively, by in situ hybridization". Genomics. 14 (2): 546–7. doi:10.1016/S0888-7543(05)80265-4. PMID 1330886.
^ "Entrez Gene: ITPKB inositol 1,4,5-trisphosphate 3-kinase B".
^ Sauer K, Cooke MP (April 2010). "Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphate". Nat. Rev. Immunol. 10 (4): 257–71. doi:10.1038/nri2745. PMC 2922113. PMID 20336153.

Function

References

Further reading