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TOMM20

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TOMM20
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTOMM20, MAS20, MOM19, TOM20, translocase of outer mitochondrial membrane 20
External IDsOMIM: 601848; MGI: 1915202; HomoloGene: 44649; GeneCards: TOMM20; OMA:TOMM20 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014765

NM_024214

RefSeq (protein)

NP_055580
NP_055580.1

NP_077176

Location (UCSC)Chr 1: 235.11 – 235.13 MbChr 8: 127.66 – 127.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitochondrial import receptor subunit TOM20 homolog is a protein that in humans is encoded by the TOMM20 gene.[5][6][7][8] TOM20 is one of the receptor systems of the TOM complex (translocase of the outer membrane) in the outer mitochondrial membrane (OMM).

Function

In mitochondrial protein import, TOM20 is closely associated with the pore-forming TOM40 complex and acts by recognizing and binding the N-terminal MTSs (matrix-targeting sequences), which form an amphipathic alpha helix and aid passage of the target proteins into the mitochondrial matrix.[9]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173726Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000093904Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Seki N, Moczko M, Nagase T, Zufall N, Ehmann B, Dietmeier K, et al. (November 1995). "A human homolog of the mitochondrial protein import receptor Mom19 can assemble with the yeast mitochondrial receptor complex". FEBS Letters. 375 (3): 307–310. doi:10.1016/0014-5793(95)01229-8. PMID 7498524. S2CID 45148104.
  6. ^ Goping IS, Millar DG, Shore GC (October 1995). "Identification of the human mitochondrial protein import receptor, huMas20p. Complementation of delta mas20 in yeast". FEBS Letters. 373 (1): 45–50. doi:10.1016/0014-5793(95)01010-C. PMID 7589431. S2CID 1204415.
  7. ^ Likić VA, Perry A, Hulett J, Derby M, Traven A, Waller RF, et al. (March 2005). "Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20". Journal of Molecular Biology. 347 (1): 81–93. doi:10.1016/j.jmb.2004.12.057. PMID 15733919.
  8. ^ "Entrez Gene: TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)".
  9. ^ Hansen KG, Herrmann JM (June 2019). "Transport of Proteins into Mitochondria". The Protein Journal. 38 (3): 330–342. doi:10.1007/s10930-019-09819-6. PMID 30868341. S2CID 76662487.

Further reading