PRPSAP1

PRPSAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2C4K
Identifiers
Aliases	PRPSAP1, PAP39, phosphoribosyl pyrophosphate synthetase-associated protein 1, phosphoribosyl pyrophosphate synthetase associated protein 1
External IDs	OMIM: 601249; MGI: 1915013; HomoloGene: 55687; GeneCards: PRPSAP1; OMA:PRPSAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	76,384,521 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	116,385,028 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; right lobe of thyroid gland; ; gonad; ; minor salivary glands; ; left lobe of thyroid gland; ; left testis; ; right testis; ; right lung; ; ventricular zone; ; right adrenal cortex;
	Top expressed in
	Paneth cell; ; internal carotid artery; ; epithelium of lens; ; external carotid artery; ; duodenum; ; crypt of lieberkuhn of small intestine; ; endothelial cell of lymphatic vessel; ; left lobe of liver; ; condyle; ; jejunum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	enzyme inhibitor activity; ribose phosphate diphosphokinase activity; magnesium ion binding; protein binding; identical protein binding; enzyme regulator activity;
Cellular component	ribose phosphate diphosphokinase complex; cytoplasm;
Biological process	nucleotide biosynthetic process; nucleobase-containing compound metabolic process; negative regulation of catalytic activity; 5-phosphoribose 1-diphosphate biosynthetic process; purine nucleotide biosynthetic process; regulation of catalytic activity;
	Sources:Amigo / QuickGO
Orthologs
	5635
	67763
	ENSG00000161542
	ENSMUSG00000015869
	Q14558
	Q9D0M1
	NM_002766; NM_001330503; NM_001366236
	NM_026364
	NP_001317432; NP_002757; NP_001353165
	NP_080640; NP_001391595; NP_001391596; NP_001391597; NP_001391598
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphoribosyl pyrophosphate synthetase-associated protein 1 is an enzyme that in humans is encoded by the PRPSAP1 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000161542 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015869 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ishizuka T, Ahmad I, Kita K, Sonoda T, Ishijima S, Sawa K, Suzuki N, Tatibana M (Jan 1997). "The human phosphoribosylpyrophosphate synthetase-associated protein 39 gene (PRPSAP1) is located in the chromosome region 17q24-q25". Genomics. 33 (2): 332–4. doi:10.1006/geno.1996.0207. PMID 8660991.
^ "Entrez Gene: PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1".

Tatibana M, Kita K, Taira M, et al. (1995). "Mammalian phosphoribosyl-pyrophosphate synthetase". Adv. Enzyme Regul. 35: 229–49. doi:10.1016/0065-2571(94)00017-W. PMID 7572345.
Kita K, Ishizuka T, Ishijima S, et al. (1994). "A novel 39-kDa phosphoribosylpyrophosphate synthetase-associated protein of rat liver. Cloning, high sequence similarity to the catalytic subunits, and a negative regulatory role". J. Biol. Chem. 269 (11): 8334–40. doi:10.1016/S0021-9258(17)37198-3. PMID 8132556.
Ishizuka T, Kita K, Sonoda T, et al. (1996). "Cloning and sequencing of human complementary DNA for the phosphoribosylpyrophosphate synthetase-associated protein 39". Biochim. Biophys. Acta. 1306 (1): 27–30. doi:10.1016/0167-4781(96)00030-9. PMID 8611620.
Ishijima S, Asai T, Kita K, et al. (1997). "Partial reconstitution of mammalian phosphoribosylpyrophosphate synthetase in Escherichia coli cells. Coexpression of catalytic subunits with the 39-kDa associated protein leads to formation of soluble multimeric complexes of various compositions". Biochim. Biophys. Acta. 1342 (1): 28–36. doi:10.1016/s0167-4838(97)00077-0. PMID 9366267.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000161542 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015869 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8660991-5] Ishizuka T, Ahmad I, Kita K, Sonoda T, Ishijima S, Sawa K, Suzuki N, Tatibana M (Jan 1997). "The human phosphoribosylpyrophosphate synthetase-associated protein 39 gene (PRPSAP1) is located in the chromosome region 17q24-q25". Genomics. 33 (2): 332–4. doi:10.1006/geno.1996.0207. PMID 8660991.

[entrez-6] "Entrez Gene: PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1".

[1]

[2]

[3]

[4]

[5]

[6]

References

Further reading