DOK5

DOK5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1J0W
Identifiers
Aliases	DOK5, C20orf180, IRS-6, IRS6, docking protein 5
External IDs	OMIM: 608334; MGI: 1924079; HomoloGene: 10195; GeneCards: DOK5; OMA:DOK5 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	54,651,169 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	170,721,689 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; pancreatic ductal cell; ; vastus lateralis muscle; ; cartilage tissue; ; Skeletal muscle tissue of rectus abdominis; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; deltoid muscle; ; Brodmann area 46;
	Top expressed in
	ventricular zone; ; visual cortex; ; primary visual cortex; ; soleus muscle; ; superior frontal gyrus; ; genital tubercle; ; dentate gyrus of hippocampal formation granule cell; ; neural tube; ; neural layer of retina; ; embryo;
	More reference expression data
	More reference expression data
Orthologs
	55816
	76829
	ENSG00000101134
	ENSMUSG00000027560
	Q9P104
	Q91ZM9
	NM_001294161; NM_018431; NM_177959
	NM_001163686; NM_029761
	NP_001281090; NP_060901; NP_808874
	NP_001157158; NP_084037
	Wikidata
View/Edit Human	View/Edit Mouse

Docking protein 5 is a protein that in humans is encoded by the DOK5 gene.^[5]^[6]

Function

The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this protein does not interact with RASGAP.^[6]

Interactions

DOK5 has been shown to interact with RET proto-oncogene.^[5]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101134 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027560 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Grimm J, Sachs M, Britsch S, Di Cesare S, Schwarz-Romond T, Alitalo K, Birchmeier W (Jul 2001). "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation" (PDF). J Cell Biol. 154 (2): 345–54. doi:10.1083/jcb.200102032. PMC 2150770. PMID 11470823.
^ ^a ^b "Entrez Gene: DOK5 docking protein 5".
^ Crowder RJ, Enomoto H, Yang M, Johnson EM, Milbrandt J (2004). "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth". J. Biol. Chem. 279 (40): 42072–81. doi:10.1074/jbc.M403726200. PMID 15286081.

Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Shi N, Zhou W, Tang K, et al. (2003). "Expression, crystallization and preliminary X-ray studies of the recombinant PTB domain of human dok-5 protein". Acta Crystallogr. D. 58 (Pt 12): 2170–2. doi:10.1107/S090744490201644X. PMID 12454490.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Favre C, Gérard A, Clauzier E, et al. (2003). "DOK4 and DOK5: new Dok-related genes expressed in human T cells". Genes Immun. 4 (1): 40–5. doi:10.1038/sj.gene.6363891. PMID 12595900.
Cai D, Dhe-Paganon S, Melendez PA, et al. (2003). "Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5". J. Biol. Chem. 278 (28): 25323–30. doi:10.1074/jbc.M212430200. PMID 12730241.
Crowder RJ, Enomoto H, Yang M, et al. (2004). "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth". J. Biol. Chem. 279 (40): 42072–81. doi:10.1074/jbc.M403726200. PMID 15286081.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Shi L, Yue J, You Y, et al. (2007). "Dok5 is substrate of TrkB and TrkC receptors and involved in neurotrophin induced MAPK activation". Cell. Signal. 18 (11): 1995–2003. doi:10.1016/j.cellsig.2006.03.007. PMID 16647839.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101134 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027560 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11470823-5] Grimm J, Sachs M, Britsch S, Di Cesare S, Schwarz-Romond T, Alitalo K, Birchmeier W (Jul 2001). "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation" (PDF). J Cell Biol. 154 (2): 345–54. doi:10.1083/jcb.200102032. PMC 2150770. PMID 11470823.

[entrez-6] "Entrez Gene: DOK5 docking protein 5".

[pmid15286081-7] Crowder RJ, Enomoto H, Yang M, Johnson EM, Milbrandt J (2004). "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth". J. Biol. Chem. 279 (40): 42072–81. doi:10.1074/jbc.M403726200. PMID 15286081.

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Function

Interactions

References

Further reading