HS2ST1

HS2ST1
Identifiers
Aliases	HS2ST1, dJ604K5.2, heparan sulfate 2-O-sulfotransferase 1, NFSRA
External IDs	OMIM: 604844; MGI: 1346049; HomoloGene: 8025; GeneCards: HS2ST1; OMA:HS2ST1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	87,109,982 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	144,275,942 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; germinal epithelium; ; endothelial cell; ; right adrenal cortex; ; left adrenal gland; ; Epithelium of choroid plexus; ; left adrenal cortex; ; ventricular zone; ; stromal cell of endometrium; ; retinal pigment epithelium;
	Top expressed in
	right lung; ; left lung; ; right lung lobe; ; left lung lobe; ; medial ganglionic eminence; ; endothelial cell of lymphatic vessel; ; vestibular sensory epithelium; ; ciliary body; ; secondary oocyte; ; iris;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; sulfotransferase activity; heparan sulfate 2-O-sulfotransferase activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; membrane;
Biological process	glycosaminoglycan biosynthetic process; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; heparan sulfate proteoglycan biosynthetic process, enzymatic modification;
	Sources:Amigo / QuickGO
Orthologs
	9653
	23908
	ENSG00000153936
	ENSMUSG00000040151
	Q7LGA3
	Q8R3H7
	NM_012262; NM_001134492
	NM_011828; NM_001355234
	NP_001127964; NP_036394
	NP_035958; NP_001342163
	Wikidata
View/Edit Human	View/Edit Mouse

Heparan sulfate 2-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS2ST1 gene.^[5]^[6]

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes heparan sulfate 2-O-sulfotransferase, a member of the heparan sulfate biosynthetic enzyme family. This family member transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate.

The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000153936 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040151 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (Feb 1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
^ ^a ^b "Entrez Gene: HS2ST1 heparan sulfate 2-O-sulfotransferase 1".

Muramatsu T (2000). "Essential roles of carbohydrate signals in development, immune response and tissue functions, as revealed by gene targeting". J. Biochem. 127 (2): 171–6. doi:10.1093/oxfordjournals.jbchem.a022590. PMID 10731680.
Rong J, Habuchi H, Kimata K, et al. (2000). "Expression of heparan sulphate L-iduronyl 2-O-sulphotransferase in human kidney 293 cells results in increased D-glucuronyl 2-O-sulphation". Biochem. J. 346 (2): 463–8. doi:10.1042/0264-6021:3460463. PMC 1220874. PMID 10677367.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Aquino RS, Landeira-Fernandez AM, Valente AP, et al. (2005). "Occurrence of sulfated galactans in marine angiosperms: evolutionary implications". Glycobiology. 15 (1): 11–20. doi:10.1093/glycob/cwh138. PMID 15317737.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Xu D, Song D, Pedersen LC, Liu J (2007). "Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase". J. Biol. Chem. 282 (11): 8356–67. doi:10.1074/jbc.M608062200. PMID 17227754.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000153936 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040151 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9455484-5] Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (Feb 1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.

[entrez-6] "Entrez Gene: HS2ST1 heparan sulfate 2-O-sulfotransferase 1".

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References

Further reading