POLR3E

POLR3E
Identifiers
Aliases	POLR3E, RPC5, SIN, polymerase (RNA) III subunit E, RNA polymerase III subunit E, C37
External IDs	OMIM: 617815; MGI: 1349452; HomoloGene: 14052; GeneCards: POLR3E; OMA:POLR3E - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	22,335,101 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	120,546,655 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; muscle of thigh; ; body of pancreas; ; left lobe of thyroid gland; ; anterior pituitary; ; right lobe of thyroid gland; ; skin of leg; ; skin of abdomen; ; right uterine tube; ; left ovary;
	Top expressed in
	right kidney; ; proximal tubule; ; human kidney; ; epiblast; ; hair follicle; ; seminiferous tubule; ; endothelial cell of lymphatic vessel; ; condyle; ; yolk sac; ; Paneth cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-directed 5'-3' RNA polymerase activity; RNA polymerase III activity;
Cellular component	RNA polymerase III complex; cytosol; nucleus; nucleoplasm;
Biological process	immune system process; defense response to virus; transcription, DNA-templated; transcription by RNA polymerase III; innate immune response; positive regulation of type I interferon production;
	Sources:Amigo / QuickGO
Orthologs
	55718
	26939
	ENSG00000284282; ENSG00000058600
	ENSMUSG00000030880
	Q9NVU0
	Q9CZT4
	NM_001258033; NM_001258034; NM_001258035; NM_001258036; NM_018119
	NM_001164096; NM_025298; NM_001379288
	NP_001244962; NP_001244963; NP_001244964; NP_001244965; NP_060589
	NP_001157568; NP_079574; NP_001366217
	Wikidata
View/Edit Human	View/Edit Mouse

DNA-directed RNA polymerase III subunit RPC5 is an enzyme that in humans is encoded by the POLR3E gene.^[5]^[6]^[7]

Interactions

POLR3E has been shown to interact with POLR3D.^[8]

Notes and references

^ ^a ^b ^c ENSG00000058600 GRCh38: Ensembl release 89: ENSG00000284282, ENSG00000058600 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030880 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–150. doi:10.1093/dnares/7.2.143. PMID 10819331.
^ Dong Z, Bell LR (Nov 1999). "SIN, a novel Drosophila protein that associates with the RNA binding protein sex-lethal". Gene. 237 (2): 421–428. doi:10.1016/S0378-1119(99)00303-0. PMID 10521666.
^ "Entrez Gene: POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)".
^ Hu, Ping; Wu Si; Sun Yuling; Yuan Chih-Chi; Kobayashi Ryuji; Myers Michael P; Nouria Hernandez (Nov 2002). "Characterization of Human RNA Polymerase III Identifies Orthologues for Saccharomyces cerevisiae RNA Polymerase III Subunits" (PDF). Mol. Cell. Biol. 22 (22). United States: 8044–8055. doi:10.1128/MCB.22.22.8044-8055.2002. ISSN 0270-7306. PMC 134740. PMID 12391170.

Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–1147. PMID 1403646.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hu P, Wu S, Sun Y, et al. (2002). "Characterization of Human RNA Polymerase III Identifies Orthologues for Saccharomyces cerevisiae RNA Polymerase III Subunits". Mol. Cell. Biol. 22 (22): 8044–8055. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740. PMID 12391170.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000058600 GRCh38: Ensembl release 89: ENSG00000284282, ENSG00000058600 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030880 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10819331-5] Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–150. doi:10.1093/dnares/7.2.143. PMID 10819331.

[pmid10521666-6] Dong Z, Bell LR (Nov 1999). "SIN, a novel Drosophila protein that associates with the RNA binding protein sex-lethal". Gene. 237 (2): 421–428. doi:10.1016/S0378-1119(99)00303-0. PMID 10521666.

[entrez-7] "Entrez Gene: POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)".

[pmid12391170-8] Hu, Ping; Wu Si; Sun Yuling; Yuan Chih-Chi; Kobayashi Ryuji; Myers Michael P; Nouria Hernandez (Nov 2002). "Characterization of Human RNA Polymerase III Identifies Orthologues for Saccharomyces cerevisiae RNA Polymerase III Subunits" (PDF). Mol. Cell. Biol. 22 (22). United States: 8044–8055. doi:10.1128/MCB.22.22.8044-8055.2002. ISSN 0270-7306. PMC 134740. PMID 12391170.

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Interactions

Notes and references

Further reading