METRN

METRN
Identifiers
Aliases	METRN, C16orf23, c380A1.2, meteorin, glial cell differentiation regulator
External IDs	OMIM: 610998; MGI: 1917333; HomoloGene: 11432; GeneCards: METRN; OMA:METRN - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	719,655 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	26,016,110 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; right uterine tube; ; caudate nucleus; ; nucleus accumbens; ; amygdala; ; right frontal lobe; ; putamen; ; anterior cingulate cortex; ; ventral tegmental area; ; anterior pituitary;
	Top expressed in
	optic nerve; ; cerebellar cortex; ; somite; ; cerebellar vermis; ; lobe of cerebellum; ; median eminence; ; interventricular septum; ; superior frontal gyrus; ; lumbar subsegment of spinal cord; ; visual cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	hormone activity;
Cellular component	extracellular region; extracellular space;
Biological process	multicellular organism development; cell differentiation; glial cell differentiation; positive regulation of axonogenesis; nervous system development; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	79006
	70083
	ENSG00000103260
	ENSMUSG00000002274
	Q9UJH8
	Q8C1Q4
	NM_024042
	NM_133719
	NP_076947
	NP_598480
	Wikidata
View/Edit Human	View/Edit Mouse

Meteorin, glial cell differentiation regulator is a protein that in humans is encoded by the METRN gene. ^[5]

Function

Meteorin regulates glial cell differentiation and promotes the formation of axonal networks during neurogenesis. Aligned with its neurotrophic properties Meteorin promotes neurotic outgrowth of cultured dorsal root ganglion sensory neurons via a mechanism that involves satellite glial cells.^[6] Meteorin also has been shown to have profound and extremely long-lasting analgesic effects in animal models of inflammatory and neuropathic pain.^[7]^[8]

The human variant of the protein is currently being developed by the Danish biotechnology company, Hoba Therapeutics,^[9] for the treatment of neuropathic pain in humans.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103260 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002274 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Meteorin, glial cell differentiation regulator". Retrieved 2016-02-25.
^ Nishino J, Yamashita K, Hashiguchi H, Fujii H, Shimazaki T, Hamada H (May 2004). "Meteorin: a secreted protein that regulates glial cell differentiation and promotes axonal extension". The EMBO Journal. 23 (9): 1998–2008. doi:10.1038/sj.emboj.7600202. PMC 404322. PMID 15085178.
^ Jørgensen JR, Xu XJ, Arnold HM, Munro G, Hao JX, Pepinsky B, Huang C, Gong BJ, Wiesenfeld-Hallin Z, Wahlberg LU, Johansen TE (October 2012). "Meteorin reverses hypersensitivity in rat models of neuropathic pain". Experimental Neurology. 237 (2): 260–6. doi:10.1016/j.expneurol.2012.06.027. PMID 22766205. S2CID 20074608.
^ Xie JY, Qu C, Munro G, Petersen KA, Porreca F (August 2019). "Antihyperalgesic effects of Meteorin in the rat chronic constriction injury model: a replication study". Pain. 160 (8): 1847–1855. doi:10.1097/j.pain.0000000000001569. PMC 6687406. PMID 31335652.
^ "HB-086 (recombinant human meteorin)". Hoba Therapeutics.

Function

References

Further reading