PCSK4

PCSK4
Identifiers
Aliases	PCSK4, PC4, SPC5, proprotein convertase subtilisin/kexin type 4
External IDs	OMIM: 600487; MGI: 97514; HomoloGene: 22495; GeneCards: PCSK4; OMA:PCSK4 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	1,490,752 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	80,329,498 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; right uterine tube; ; testicle; ; anterior pituitary; ; right lobe of liver; ; right frontal lobe; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; olfactory zone of nasal mucosa;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; internal carotid artery; ; external carotid artery; ; neural layer of retina; ; outer nuclear layer; ; embryo; ; proximal tubule; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; hydrolase activity; protein binding; serine-type endopeptidase activity;
Cellular component	integral component of membrane; membrane; acrosomal membrane; cytoplasmic vesicle; acrosomal vesicle; trans-Golgi network; integral component of Golgi membrane;
Biological process	proteolysis; binding of sperm to zona pellucida; sperm capacitation; acrosome reaction; fertilization; reproductive process; protein processing; peptide hormone processing;
	Sources:Amigo / QuickGO
Orthologs
	54760
	18551
	ENSG00000115257
	ENSMUSG00000020131
	Q6UW60
	P29121
	NM_017573; NM_001395257
	NM_008793
	NP_060043
	NP_032819
	Wikidata
View/Edit Human	View/Edit Mouse

Proprotein convertase subtilisin/kexin type 4 is an enzyme that in humans is encoded by the PCSK4 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115257 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020131 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mbikay M, Seidah NG, Chretien M, Simpson EM (Jul 1995). "Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human". Genomics. 26 (1): 123–9. doi:10.1016/0888-7543(95)80090-9. PMID 7782070.
^ "Entrez Gene: PCSK4 proprotein convertase subtilisin/kexin type 4".

Seidah NG, Chrétien M, Day R (1995). "The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions". Biochimie. 76 (3–4): 197–209. doi:10.1016/0300-9084(94)90147-3. PMID 7819324.
Bassi DE, Mahloogi H, Klein-Szanto AJ (2000). "The proprotein convertases furin and PACE4 play a significant role in tumor progression". Mol. Carcinog. 28 (2): 63–9. doi:10.1002/1098-2744(200006)28:2<63::AID-MC1>3.0.CO;2-C. PMID 10900462. S2CID 22849623.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Malik S, Guermah M, Roeder RG (1998). "A dynamic model for PC4 coactivator function in RNA polymerase II transcription". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2192–7. Bibcode:1998PNAS...95.2192M. doi:10.1073/pnas.95.5.2192. PMC 19292. PMID 9482861.
Wang Z, Roeder RG (1998). "DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III". Mol. Cell. 1 (5): 749–57. doi:10.1016/S1097-2765(00)80074-X. PMID 9660958.
Li M, Mbikay M, Nakayama K, et al. (2001). "Prohormone convertase PC4 processes the precursor of PACAP in the testis". Ann. N. Y. Acad. Sci. 921: 333–9. doi:10.1111/j.1749-6632.2000.tb06988.x. PMID 11193847. S2CID 46125753.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Qiu Q, Basak A, Mbikay M, et al. (2005). "Role of pro-IGF-II processing by proprotein convertase 4 in human placental development". Proc. Natl. Acad. Sci. U.S.A. 102 (31): 11047–52. Bibcode:2005PNAS..10211047Q. doi:10.1073/pnas.0502357102. PMC 1182422. PMID 16040806.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115257 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020131 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7782070-5] Mbikay M, Seidah NG, Chretien M, Simpson EM (Jul 1995). "Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human". Genomics. 26 (1): 123–9. doi:10.1016/0888-7543(95)80090-9. PMID 7782070.

[entrez-6] "Entrez Gene: PCSK4 proprotein convertase subtilisin/kexin type 4".

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References

Further reading