From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Myosin phosphatase Rho-interacting protein is an enzyme that in humans is encoded by the MPRIP gene .[ 5] [ 6]
Interactions
M-RIP has been shown to interact with RHOA .[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000133030 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005417 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 5 (6): 355–64. doi :10.1093/dnares/5.6.355 PMID 10048485 . ^ "Entrez Gene: M-RIP myosin phosphatase-Rho interacting protein" .^ Gebbink MF, Kranenburg O, Poland M, van Horck FP, Houssa B, Moolenaar WH (Jun 1997). "Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology" . J. Cell Biol . 137 (7): 1603–13. doi :10.1083/jcb.137.7.1603 . PMC 2137826 PMID 9199174 .
Further reading
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Gebbink MF, Kranenburg O, Poland M, van Horck FP, Houssa B, Moolenaar WH (1997). "Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology" . J. Cell Biol . 137 (7): 1603–13. doi :10.1083/jcb.137.7.1603 . PMC 2137826 PMID 9199174 . Surks HK, Richards CT, Mendelsohn ME (2004). "Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA" . J. Biol. Chem . 278 (51): 51484–93. doi :10.1074/jbc.M305622200 PMID 14506264 . Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol . 6 (2): 97–105. doi :10.1038/ncb1086 . PMID 14743216 . S2CID 11683986 . Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization" . Curr. Biol . 14 (16): 1436–50. doi :10.1016/j.cub.2004.07.051 PMID 15324660 . S2CID 2371325 . Mulder J, Ariaens A, van den Boomen D, Moolenaar WH (2005). "p116Rip targets myosin phosphatase to the actin cytoskeleton and is essential for RhoA/ROCK-regulated neuritogenesis" . Mol. Biol. Cell . 15 (12): 5516–27. doi :10.1091/mbc.E04-04-0275 . PMC 532030 PMID 15469989 . Koga Y, Ikebe M (2005). "p116Rip decreases myosin II phosphorylation by activating myosin light chain phosphatase and by inactivating RhoA" . J. Biol. Chem . 280 (6): 4983–91. doi :10.1074/jbc.M410909200 PMID 15545284 . Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer" . Mol. Cell. Proteomics . 4 (6): 785–95. doi :10.1074/mcp.M500021-MCP200 PMID 15778465 . Surks HK, Riddick N, Ohtani K (2006). "M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells" . J. Biol. Chem . 280 (52): 42543–51. doi :10.1074/jbc.M506863200 PMID 16257966 . Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 . Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 PMID 17353931 .
