PAPOLG

PAPOLG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4LT6
Identifiers
Aliases	PAPOLG, poly(A) polymerase gamma
External IDs	OMIM: 616865; MGI: 2442119; HomoloGene: 56959; GeneCards: PAPOLG; OMA:PAPOLG - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	60,802,086 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	23,845,253 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; testicle; ; Brodmann area 23; ; gonad; ; ganglionic eminence; ; buccal mucosa cell; ; ventricular zone; ; primary visual cortex; ; tibia; ; thyroid gland;
	Top expressed in
	secondary oocyte; ; zygote; ; atrioventricular valve; ; primary oocyte; ; endocardial cushion; ; genital tubercle; ; medullary collecting duct; ; mandibular prominence; ; maxillary prominence; ; pineal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; nucleotidyltransferase activity; polynucleotide adenylyltransferase activity; ATP binding; metal ion binding; RNA binding;
Cellular component	membrane; nucleus; nucleoplasm; cytosol; nuclear body;
Biological process	mRNA polyadenylation; mRNA processing; RNA polyadenylation; RNA 3'-end processing;
	Sources:Amigo / QuickGO
Orthologs
	64895
	216578
	ENSG00000115421
	ENSMUSG00000020273
	Q9BWT3
	Q6PCL9
	NM_022894
	NM_172555
	NP_075045
	NP_766143
	Wikidata
View/Edit Human	View/Edit Mouse

Poly(A) polymerase gamma is an enzyme that in humans is encoded by the PAPOLG gene.^[5]

This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. This gene is located on chromosome 2 in contrast to the PAPII gene, which is located on chromosome 14.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115421 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020273 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: PAPOLG poly(A) polymerase gamma".

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Topalian SL, Kaneko S, Gonzales MI, et al. (2001). "Identification and functional characterization of neo-poly(A) polymerase, an RNA processing enzyme overexpressed in human tumors". Mol. Cell. Biol. 21 (16): 5614–23. doi:10.1128/MCB.21.16.5614-5623.2001. PMC 87282. PMID 11463842.
Kyriakopoulou CB, Nordvarg H, Virtanen A (2001). "A novel nuclear human poly(A) polymerase (PAP), PAP gamma". J. Biol. Chem. 276 (36): 33504–11. doi:10.1074/jbc.M104599200. PMID 11431479.
Perumal K, Sinha K, Henning D, Reddy R (2001). "Purification, characterization, and cloning of the cDNA of human signal recognition particle RNA 3'-adenylating enzyme". J. Biol. Chem. 276 (24): 21791–6. doi:10.1074/jbc.M101905200. PMID 11287430.
Weichs an der Glon C, Ashe M, Eggermont J, Proudfoot NJ (1993). "Tat-dependent occlusion of the HIV poly(A) site". EMBO J. 12 (5): 2119–28. doi:10.1002/j.1460-2075.1993.tb05860.x. PMC 413433. PMID 8491200.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115421 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020273 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PAPOLG poly(A) polymerase gamma".

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References

Further reading