IFT57

IFT57
Identifiers
Aliases	IFT57, ESRRBL1, HIPPI, MHS4R2, intraflagellar transport 57, OFD18
External IDs	OMIM: 606621; MGI: 1921166; HomoloGene: 32383; GeneCards: IFT57; OMA:IFT57 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	108,222,435 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	49,585,489 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; sperm; ; caput epididymis; ; left testis; ; mucosa of paranasal sinus; ; right testis; ; olfactory zone of nasal mucosa; ; epithelium of nasopharynx; ; corpus epididymis; ; right uterine tube;
	Top expressed in
	Epithelium of choroid plexus; ; fossa; ; islet of Langerhans; ; seminiferous tubule; ; condyle; ; ciliary body; ; barrel cortex; ; vestibular sensory epithelium; ; lateral geniculate nucleus; ; medial geniculate nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding;
Cellular component	intraciliary transport particle B; cytoplasm; ciliary basal body; centrosome; Golgi apparatus; cell projection; photoreceptor connecting cilium; dendrite terminus; ciliary tip; axoneme; cytoskeleton; cilium;
Biological process	regulation of apoptotic process; regulation of transcription, DNA-templated; intraciliary transport; transcription, DNA-templated; heart looping; neural tube closure; negative regulation of epithelial cell proliferation; smoothened signaling pathway; left/right pattern formation; activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process; intraciliary transport involved in cilium assembly; motile cilium assembly; non-motile cilium assembly; cilium assembly;
	Sources:Amigo / QuickGO
Orthologs
	55081
	73916
	ENSG00000114446
	ENSMUSG00000032965
	Q9NWB7
	Q8BXG3
	NM_018010
	NM_028680
	NP_060480
	NP_082956
	Wikidata
View/Edit Human	View/Edit Mouse

Intraflagellar transport protein 57 homolog is a protein that in humans is encoded by the IFT57 gene.^[5]

Interactions

IFT57 has been shown to interact with Caspase 8.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000114446 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032965 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: IFT57 intraflagellar transport 57 homolog (Chlamydomonas)".
^ Gervais FG, Singaraja R, Xanthoudakis S, Gutekunst CA, Leavitt BR, Metzler M, Hackam AS, Tam J, Vaillancourt JP, Houtzager V, Rasper DM, Roy S, Hayden MR, Nicholson DW (Feb 2002). "Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi". Nat. Cell Biol. 4 (2): 95–105. doi:10.1038/ncb735. PMID 11788820. S2CID 10439592.

Gervais FG, Singaraja R, Xanthoudakis S, Gutekunst CA, Leavitt BR, Metzler M, Hackam AS, Tam J, Vaillancourt JP, Houtzager V, Rasper DM, Roy S, Hayden MR, Nicholson DW (2002). "Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi". Nat. Cell Biol. 4 (2): 95–105. doi:10.1038/ncb735. PMID 11788820. S2CID 10439592.
Mattson MP (2002). "Accomplices to neuronal death". Nature. 415 (6870): 377–9. doi:10.1038/415377a. PMID 11807533. S2CID 39428123.
Cheng CM, Huang SP, Chang YF, Chung WY, Yuo CY (2003). "The viral death protein Apoptin interacts with Hippi, the protein interactor of Huntingtin-interacting protein 1". Biochem. Biophys. Res. Commun. 305 (2): 359–64. doi:10.1016/S0006-291X(03)00764-2. PMID 12745083.
Baker SA, Freeman K, Luby-Phelps K, Pazour GJ, Besharse JC (2003). "IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia". J. Biol. Chem. 278 (36): 34211–8. doi:10.1074/jbc.M300156200. PMID 12821668.
Fan Y, Esmail MA, Ansley SJ, Blacque OE, Boroevich K, Ross AJ, Moore SJ, Badano JL, May-Simera H, Compton DS, Green JS, Lewis RA, van Haelst MM, Parfrey PS, Baillie DL, Beales PL, Katsanis N, Davidson WS, Leroux MR (2004). "Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome". Nat. Genet. 36 (9): 989–93. doi:10.1038/ng1414. PMID 15314642.
Majumder P, Chattopadhyay B, Mazumder A, Das P, Bhattacharyya NP (2006). "Induction of apoptosis in cells expressing exogenous Hippi, a molecular partner of huntingtin-interacting protein Hip1". Neurobiol. Dis. 22 (2): 242–56. doi:10.1016/j.nbd.2005.11.003. PMID 16364650. S2CID 23232258.
Banerjee M, Majumder P, Bhattacharyya NP, Dattagupta JK, Sen U (2006). "Cloning, expression, purification, crystallization and preliminary crystallographic analysis of pseudo death-effector domain of HIPPI, a molecular partner of Huntingtin-interacting protein HIP-1". Acta Crystallographica Section F. 62 (Pt 12): 1247–50. doi:10.1107/S1744309106046628. PMC 2225382. PMID 17142908.
Majumder P, Chattopadhyay B, Sukanya S, Ray T, Banerjee M, Mukhopadhyay D, Bhattacharyya NP (2007). "Interaction of HIPPI with putative promoter sequence of caspase-1 in vitro and in vivo". Biochem. Biophys. Res. Commun. 353 (1): 80–5. doi:10.1016/j.bbrc.2006.11.138. PMID 17173859.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000114446 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032965 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: IFT57 intraflagellar transport 57 homolog (Chlamydomonas)".

[pmid11788820-6] Gervais FG, Singaraja R, Xanthoudakis S, Gutekunst CA, Leavitt BR, Metzler M, Hackam AS, Tam J, Vaillancourt JP, Houtzager V, Rasper DM, Roy S, Hayden MR, Nicholson DW (Feb 2002). "Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi". Nat. Cell Biol. 4 (2): 95–105. doi:10.1038/ncb735. PMID 11788820. S2CID 10439592.

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Interactions

References

Further reading