Prefoldin subunit 6

PFDN6
Identifiers
Aliases	PFDN6, H2-KE2, HKE2, KE-2, PFD6, prefoldin subunit 6
External IDs	OMIM: 605660; MGI: 95908; HomoloGene: 40720; GeneCards: PFDN6; OMA:PFDN6 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	33,298,401 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,159,317 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; Hypothalamus; ; islet of Langerhans; ; Brodmann area 9; ; hippocampus proper; ; Amygdala; ; mucosa of transverse colon; ; substantia nigra; ; caudate nucleus;
	Top expressed in
	primitive streak; ; yolk sac; ; epiblast; ; medial ganglionic eminence; ; neural layer of retina; ; fossa; ; morula; ; morula; ; embryo; ; condyle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	unfolded protein binding; chaperone binding;
Cellular component	cytoplasm; prefoldin complex;
Biological process	chaperone-mediated protein complex assembly; protein folding;
	Sources:Amigo / QuickGO
Orthologs
	10471
	14976
ENSG00000237335; ENSG00000204220; ENSG00000235692; ENSG00000206283; ENSG00000224782;
	n/a
	ENSMUSG00000024309
	O15212; Q5STK2
	Q03958
	NM_014260; NM_001185181; NM_001265595; NM_001265596
	NM_001185182; NM_010385
NP_001172110; NP_001252524; NP_001252525; NP_055075; NP_001172110.1;
	NP_001252524.1; NP_001252525.1; NP_055075.1
	NP_001172111; NP_034515
	Wikidata
View/Edit Human	View/Edit Mouse

Prefoldin subunit 6 is a protein that in humans is encoded by the PFDN6 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c ENSG00000204220, ENSG00000235692, ENSG00000206283, ENSG00000224782 GRCh38: Ensembl release 89: ENSG00000237335, ENSG00000204220, ENSG00000235692, ENSG00000206283, ENSG00000224782 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024309 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Herberg JA, Beck S, Trowsdale J (May 1998). "TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC". J Mol Biol. 277 (4): 839–57. doi:10.1006/jmbi.1998.1637. PMID 9545376.
^ Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ (Jul 1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin". Cell. 93 (5): 863–73. doi:10.1016/S0092-8674(00)81446-4. PMID 9630229. S2CID 16011829.
^ "Entrez Gene: PFDN6 prefoldin subunit 6".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Herberg JA, Sgouros J, Jones T, et al. (1998). "Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC". Eur. J. Immunol. 28 (2): 459–67. doi:10.1002/(SICI)1521-4141(199802)28:02<459::AID-IMMU459>3.0.CO;2-Z. PMID 9521053.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Simons CT, Staes A, Rommelaere H, et al. (2004). "Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding". J. Biol. Chem. 279 (6): 4196–203. doi:10.1074/jbc.M306053200. PMID 14634002.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ostrov DA, Barnes CL, Smith LE, et al. (2007). "Characterization of HKE2: an ancient antigen encoded in the major histocompatibility complex". Tissue Antigens. 69 (2): 181–8. doi:10.1111/j.1399-0039.2006.00730.x. PMID 17257322.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000204220, ENSG00000235692, ENSG00000206283, ENSG00000224782 GRCh38: Ensembl release 89: ENSG00000237335, ENSG00000204220, ENSG00000235692, ENSG00000206283, ENSG00000224782 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024309 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9545376-5] Herberg JA, Beck S, Trowsdale J (May 1998). "TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC". J Mol Biol. 277 (4): 839–57. doi:10.1006/jmbi.1998.1637. PMID 9545376.

[pmid9630229-6] Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ (Jul 1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin". Cell. 93 (5): 863–73. doi:10.1016/S0092-8674(00)81446-4. PMID 9630229. S2CID 16011829.

[entrez-7] "Entrez Gene: PFDN6 prefoldin subunit 6".

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References

Further reading