RAB38

RAB38
Identifiers
Aliases	RAB38, NY-MEL-1, rrGTPbp, member RAS oncogene family
External IDs	OMIM: 606281; MGI: 1919683; HomoloGene: 21353; GeneCards: RAB38; OMA:RAB38 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	88,175,443 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	88,140,780 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; palpebral conjunctiva; ; skin of thigh; ; vulva; ; human penis; ; skin of abdomen; ; hair follicle; ; germinal epithelium; ; oral cavity; ; right adrenal cortex;
	Top expressed in
	zygote; ; primary oocyte; ; secondary oocyte; ; molar; ; iris; ; epidermis; ; hair follicle; ; skin of external ear; ; skin of abdomen; ; cornea;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	AP-2 adaptor complex binding; nucleotide binding; BLOC-2 complex binding; GTP binding; GTP-dependent protein binding; protein binding; AP-3 adaptor complex binding; AP-1 adaptor complex binding; GTPase activity;
Cellular component	cytoplasm; vesicle; phagocytic vesicle membrane; Golgi apparatus; membrane; melanosome; plasma membrane; early endosome; phagocytic vesicle; endoplasmic reticulum; early endosome lumen; cytoplasmic vesicle; lysosome; mitochondrion; mitochondria associated membranes; cytosol; melanosome membrane; trans-Golgi network;
Biological process	protein localization to membrane; platelet dense granule organization; organelle organization; phagosome acidification; endosome to melanosome transport; protein transport; melanosome assembly; mitochondrion organization; vesicle-mediated transport; small GTPase mediated signal transduction; post-translational protein modification; positive regulation of phosphatidylcholine biosynthetic process; intracellular protein transport; Rab protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	23682
	72433
	ENSG00000123892
	ENSMUSG00000030559
	P57729
	Q8QZZ8
	NM_022337
	NM_028238
	NP_071732; NP_071732.1
	NP_082514
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-related protein Rab-38 is a protein that in humans is encoded by the RAB38 gene.^[5]^[6]

In melanocytic cells RAB38 gene expression may be regulated by MITF.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123892 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030559 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jager D, Stockert E, Jager E, Gure AO, Scanlan MJ, Knuth A, Old LJ, Chen YT (Aug 2000). "Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library". Cancer Res. 60 (13): 3584–91. PMID 10910072.
^ "Entrez Gene: RAB38 RAB38, member RAS oncogene family".
^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Suzuki T, Miyamura Y, Inagaki K, Tomita Y (2004). "Characterization of the human RAB38 and RAB7 genes: exclusion of new major pathological loci for Japanese OCA". J. Dermatol. Sci. 32 (2): 131–6. doi:10.1016/S0923-1811(03)00071-9. PMID 12850305.
Basrur V, Yang F, Kushimoto T, et al. (2003). "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins". J. Proteome Res. 2 (1): 69–79. doi:10.1021/pr025562r. PMID 12643545.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Osanai K, Iguchi M, Takahashi K, et al. (2001). "Expression and Localization of a Novel Rab Small G Protein (Rab38) in the Rat Lung". Am. J. Pathol. 158 (5): 1665–75. doi:10.1016/S0002-9440(10)64122-3. PMC 1891947. PMID 11337364.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000123892 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030559 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10910072-5] Jager D, Stockert E, Jager E, Gure AO, Scanlan MJ, Knuth A, Old LJ, Chen YT (Aug 2000). "Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library". Cancer Res. 60 (13): 3584–91. PMID 10910072.

[entrez-6] "Entrez Gene: RAB38 RAB38, member RAS oncogene family".

[pmid19067971-7] Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

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References

Further reading