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Chemical compound
Proscillaridin Other names 14β-Hydroxy-3β-[α-L -rhamnopyranosyl)oxy]bufa-4,20,22-trienolide AHFS /Drugs.com International Drug Names ATC code
5-[(3S ,8R ,9S ,10R ,13R ,14S ,17R )-14-Hydroxy- 10,13-dimethyl-3-((2R ,3R ,4R ,5R ,6R )-3,4,5-trihydroxy- 6-methyltetrahydro-2H -pyran-2-yloxy)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro- 1H -cyclopenta[a ]phenanthren-17-yl]-2H -pyran-2-one
CAS Number PubChem CID ChemSpider UNII ChEMBL CompTox Dashboard (EPA ) ECHA InfoCard 100.006.702 Formula C 30 H 42 O 8 Molar mass 530.650 g·mol−1 3D model (JSmol )
O=C\1O\C=C(/C=C/1)[C@H]2CC[C@@]6(O)[C@]2(C)CC[C@H]5[C@H]6CC/C4=C/[C@@H](O[C@@H]3O[C@H]([C@H](O)[C@@H](O)[C@H]3O)C)CC[C@@]45C
InChI=1S/C30H42O8/c1-16-24(32)25(33)26(34)27(37-16)38-19-8-11-28(2)18(14-19)5-6-22-21(28)9-12-29(3)20(10-13-30(22,29)35)17-4-7-23(31)36-15-17/h4,7,14-16,19-22,24-27,32-35H,5-6,8-13H2,1-3H3/t16-,19-,20+,21-,22+,24-,25+,26+,27-,28-,29+,30-/m0/s1
Y Key:MYEJFUXQJGHEQK-ALRJYLEOSA-N
Y
N Y (what is this?) (verify)
Proscillaridin is a cardiac glycoside , a kind of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). It is of the bufanolide type and can be obtained from plants of the genus Scilla and in Drimia maritima (Scilla maritima ).[ 1]
The aglycone of proscillaridin is scillarenin .
References
^ Kedra M, Kedrowa S (May 1968). "[Clinical evaluation of Proscillaridin A, a glycoside of Scilla maritima]". Polski Tygodnik Lekarski . 23 (19): 714–6. PMID 4876207 .