From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Integrator complex subunit 6 is a protein that in humans is encoded by the INTS6 gene .[ 5] [ 6] [ 7]
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases . The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene.[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000102786 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035161 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Wieland I, Arden KC, Michels D, Klein-Hitpass L, Bohm M, Viars CS, Weidle UH (Oct 1999). "Isolation of DICE1: a gene frequently affected by LOH and downregulated in lung carcinomas" . Oncogene . 18 (32): 4530–7. doi :10.1038/sj.onc.1202806 PMID 10467397 . ^ Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R (Oct 2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II" . Cell . 123 (2): 265–76. doi :10.1016/j.cell.2005.08.019 PMID 16239144 . ^ a b "Entrez Gene: INTS6 integrator complex subunit 6" .
Further reading
Buchsbaum S, Morris C, Bochard V, Jalinot P (2007). "Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle" . Oncogene . 26 (35): 5132–44. doi :10.1038/sj.onc.1210314 PMID 17310990 . Hernández M, Papadopoulos N, Almeida TA (2006). "Absence of mutations in DICE1/DDX26 gene in human cancer cell lines with frequent 13q14 deletions". Cancer Genet. Cytogenet . 163 (1): 91–2. doi :10.1016/j.cancergencyto.2005.04.014 . PMID 16271964 . Röpke A, Buhtz P, Böhm M, et al. (2005). "Promoter CpG hypermethylation and downregulation of DICE1 expression in prostate cancer" . Oncogene . 24 (44): 6667–75. doi :10.1038/sj.onc.1208824 PMID 16007164 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Wieland I, Sell C, Weidle UH, Wieacker P (2005). "Ectopic expression of DICE1 suppresses tumor cell growth". Oncol. Rep . 12 (2): 207–11. doi :10.3892/or.12.2.207 . PMID 15254679 . Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13" . Nature . 428 (6982): 522–8. Bibcode :2004Natur.428..522D . doi :10.1038/nature02379 . PMC 2665288 PMID 15057823 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Li WJ, Hu N, Su H, et al. (2003). "Allelic loss on chromosome 13q14 and mutation in deleted in cancer 1 gene in esophageal squamous cell carcinoma" . Oncogene . 22 (2): 314–8. doi :10.1038/sj.onc.1206098 PMID 12527901 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Wieland I, Röpke A, Stumm M, et al. (2002). "Molecular characterization of the DICE1 (DDX26) tumor suppressor gene in lung carcinoma cells" . Oncol. Res . 12 (11–12): 491–500. doi :10.3727/096504001108747503 PMID 11939413 . Camargo AA, Nunes DN, Samaia HB, et al. (2002). "Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12" . Braz. J. Med. Biol. Res . 34 (10): 1237–45. doi :10.1590/s0100-879x2001001000002 PMID 11593297 .
