INTS6

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INTS6
Identifiers
Aliases INTS6, DBI-1, DDX26, DDX26A, DICE1, HDB, INT6, Notchl2, integrator complex subunit 6
External IDs MGI: 1202397 HomoloGene: 8121 GeneCards: INTS6
RNA expression pattern
PBB GE INTS6 218819 at fs.png

PBB GE INTS6 222239 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001039937
NM_001039938
NM_001306091
NM_012141

NM_008715

RefSeq (protein)

NP_001035026
NP_001035027
NP_001293020
NP_036273

NP_032741.2
NP_032741

Location (UCSC) Chr 13: 51.35 – 51.45 Mb Chr 14: 62.68 – 62.76 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Integrator complex subunit 6 is a protein that in humans is encoded by the INTS6 gene.[3][4][5]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Wieland I, Arden KC, Michels D, Klein-Hitpass L, Bohm M, Viars CS, Weidle UH (Oct 1999). "Isolation of DICE1: a gene frequently affected by LOH and downregulated in lung carcinomas". Oncogene. 18 (32): 4530–7. doi:10.1038/sj.onc.1202806. PMID 10467397. 
  4. ^ Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R (Oct 2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi:10.1016/j.cell.2005.08.019. PMID 16239144. 
  5. ^ a b "Entrez Gene: INTS6 integrator complex subunit 6". 

Further reading[edit]