From Wikipedia, the free encyclopedia
Protein-coding gene in humans
C-type lectin domain family 1 member B is a protein that in humans is encoded by the CLEC1B gene .[ 5] [ 6] [ 7]
Natural killer (NK) cells express multiple calcium -dependent (C-type) lectin -like receptors , such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells.[supplied by OMIM][ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000165682 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030159 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Colonna M, Samaridis J, Angman L (Mar 2000). "Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells" . Eur J Immunol . 30 (2): 697–704. doi :10.1002/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M . PMID 10671229 .
^ Sobanov Y, Bernreiter A, Derdak S, Mechtcheriakova D, Schweighofer B, Duchler M, Kalthoff F, Hofer E (Dec 2001). "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex". Eur J Immunol . 31 (12): 3493–503. doi :10.1002/1521-4141(200112)31:12<3493::AID-IMMU3493>3.0.CO;2-9 . PMID 11745369 . S2CID 42415487 .
^ a b "Entrez Gene: CLEC1B C-type lectin domain family 1, member B" .
External links
Further reading
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment" . Genome Res . 13 (10): 2265–70. doi :10.1101/gr.1293003 . PMC 403697 . PMID 12975309 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Suzuki-Inoue K, Fuller GL, García A, et al. (2006). "A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2" . Blood . 107 (2): 542–9. doi :10.1182/blood-2005-05-1994 . PMID 16174766 . S2CID 168505 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 .
Watson AA, O'Callaghan CA (2006). "Crystallization and X-ray diffraction analysis of human CLEC-2" . Acta Crystallographica Section F . 61 (Pt 12): 1094–6. doi :10.1107/S1744309105037991 . PMC 1978148 . PMID 16511244 .
Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12" . Nature . 440 (7082): 346–51. Bibcode :2006Natur.440..346S . doi :10.1038/nature04569 . PMID 16541075 .
Chaipan C, Soilleux EJ, Simpson P, et al. (2006). "DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets" . J. Virol . 80 (18): 8951–60. doi :10.1128/JVI.00136-06 . PMC 1563896 . PMID 16940507 .
Watson AA, Brown J, Harlos K, et al. (2007). "The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2" . J. Biol. Chem . 282 (5): 3165–72. doi :10.1074/jbc.M610383200 . PMID 17132623 .
Suzuki-Inoue K, Kato Y, Inoue O, et al. (2007). "Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells" . J. Biol. Chem . 282 (36): 25993–6001. doi :10.1074/jbc.M702327200 . PMID 17616532 .
Watson AA, Eble JA, O'Callaghan CA (2008). "Crystal structure of rhodocytin, a ligand for the platelet-activating receptor CLEC-2" . Protein Science . 17 (9): 1611–6. doi :10.1110/ps.035568.108 . PMC 2525532 . PMID 18583525 .