CLEC1B

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CLEC1B
Protein CLEC1B PDB 2c6u.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CLEC1B, 1810061I13Rik, CLEC2, CLEC2B, PRO1384, QDED721, C-type lectin domain family 1 member B
External IDs MGI: 1913287 HomoloGene: 49468 GeneCards: CLEC1B
Gene location (Human)
Chromosome 12 (human)
Chr. Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for CLEC1B
Genomic location for CLEC1B
Band 12p13.31-p13.2 Start 9,985,642 bp[1]
End 10,013,424 bp[1]
RNA expression pattern
PBB GE CLEC1B 220496 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001099431
NM_016509

NM_001204239
NM_001204253
NM_019985

RefSeq (protein)

NP_001092901
NP_057593

NP_001191168
NP_001191182
NP_064369

Location (UCSC) Chr 12: 9.99 – 10.01 Mb Chr 6: 129.4 – 129.41 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

C-type lectin domain family 1 member B is a protein that in humans is encoded by the CLEC1B gene.[5][6][7]

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells.[supplied by OMIM][7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165682 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030159 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Colonna M, Samaridis J, Angman L (Mar 2000). "Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells". Eur J Immunol. 30 (2): 697–704. doi:10.1002/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M. PMID 10671229. 
  6. ^ Sobanov Y, Bernreiter A, Derdak S, Mechtcheriakova D, Schweighofer B, Duchler M, Kalthoff F, Hofer E (Dec 2001). "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex". Eur J Immunol. 31 (12): 3493–503. doi:10.1002/1521-4141(200112)31:12<3493::AID-IMMU3493>3.0.CO;2-9. PMID 11745369. 
  7. ^ a b "Entrez Gene: CLEC1B C-type lectin domain family 1, member B". 

External links[edit]

Further reading[edit]