CABLES1

CABLES1
Identifiers
Aliases	CABLES1, CABL1, CABLES, HsT2563, IK3-1, Cdk5 and Abl enzyme substrate 1
External IDs	OMIM: 609194; MGI: 1927065; HomoloGene: 11097; GeneCards: CABLES1; OMA:CABLES1 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	23,260,470 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	12,078,687 bp
RNA expression pattern
	Top expressed in
	putamen; ; nucleus accumbens; ; caudate nucleus; ; internal globus pallidus; ; external globus pallidus; ; amygdala; ; pars reticulata; ; right frontal lobe; ; entorhinal cortex; ; cingulate gyrus;
	Top expressed in
	habenula; ; cumulus cell; ; lumbar subsegment of spinal cord; ; nucleus of stria terminalis; ; lacrimal gland; ; otic vesicle; ; substantia nigra; ; central gray substance of midbrain; ; Paneth cell; ; suprachiasmatic nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; cytosol; nucleus;
Biological process	cell cycle; regulation of cell cycle; cell division; nervous system development;
	Sources:Amigo / QuickGO
Orthologs
	91768
	63955
	ENSG00000134508
	ENSMUSG00000040957
	Q8TDN4
	Q9ESJ1
	NM_001100619; NM_001256438; NM_138375
	NM_001146287; NM_022021
	NP_001094089; NP_001243367; NP_612384
	NP_001139759; NP_071304
	Wikidata
View/Edit Human	View/Edit Mouse

CDK5 and ABL1 enzyme substrate 1 is a protein that in humans is encoded by the CABLES1 gene.^[5]^[6]

CABLES1 is a cyclin-dependent kinase (CDK)-binding protein that plays a role in proliferation and/or cell differentiation (Zukerberg et al., 2004).[supplied by OMIM].^[6] It is a tumor suppressor gene which losing it (by mutations, knockout, knockdown or inactivation) may lead to colorectal cancer CRC.^{[citation needed]}

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134508 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040957 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
^ ^a ^b "Entrez Gene: CABLES1 Cdk5 and Abl enzyme substrate 1".

External links

Human CABLES1 genome location and CABLES1 gene details page in the UCSC Genome Browser.

Matsuoka M, Matsuura Y, Semba K, Nishimoto I (2000). "Molecular cloning of a cyclin-like protein associated with cyclin-dependent kinase 3 (cdk 3) in vivo". Biochem. Biophys. Res. Commun. 273 (2): 442–7. doi:10.1006/bbrc.2000.2965. PMID 10873625.
Zukerberg LR, Patrick GN, Nikolic M, et al. (2000). "Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth" (PDF). Neuron. 26 (3): 633–46. doi:10.1016/S0896-6273(00)81200-3. hdl:1721.1/83489. PMID 10896159. S2CID 15142577.
Yamochi T, Nishimoto I, Okuda T, Matsuoka M (2001). "ik3-1/Cables is associated with Trap and Pctaire2". Biochem. Biophys. Res. Commun. 286 (5): 1045–50. doi:10.1006/bbrc.2001.5493. PMID 11527406.
Wu CL, Kirley SD, Xiao H, et al. (2001). "Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers". Cancer Res. 61 (19): 7325–32. PMID 11585773.
Tsuji K, Mizumoto K, Yamochi T, et al. (2002). "Differential effect of ik3-1/cables on p53- and p73-induced cell death". J. Biol. Chem. 277 (4): 2951–7. doi:10.1074/jbc.M108535200. PMID 11706030.
Yamochi T, Semba K, Tsuji K, et al. (2002). "ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3)". Eur. J. Biochem. 268 (23): 6076–82. doi:10.1046/j.0014-2956.2001.02555.x. PMID 11733001.
Sato H, Nishimoto I, Matsuoka M (2002). "ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl". Biochim. Biophys. Acta. 1574 (2): 157–63. doi:10.1016/S0167-4781(01)00367-0. PMID 11955625.
Tan D, Kirley S, Li Q, et al. (2003). "Loss of cables protein expression in human non-small cell lung cancer: a tissue microarray study". Hum. Pathol. 34 (2): 143–9. doi:10.1053/hupa.2003.26. PMID 12612882.
Dong Q, Kirley S, Rueda B, et al. (2004). "Loss of cables, a novel gene on chromosome 18q, in ovarian cancer". Mod. Pathol. 16 (9): 863–8. doi:10.1097/01.MP.0000084434.88269.0A. PMID 13679449.
Matsuoka M, Sudo H, Tsuji K, et al. (2004). "ik3-2, a relative to ik3-1/Cables, is involved in both p53-mediated and p53-independent apoptotic pathways". Biochem. Biophys. Res. Commun. 312 (2): 520–9. doi:10.1016/j.bbrc.2003.10.142. PMID 14637168.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Zukerberg LR, DeBernardo RL, Kirley SD, et al. (2004). "Loss of cables, a cyclin-dependent kinase regulatory protein, is associated with the development of endometrial hyperplasia and endometrial cancer". Cancer Res. 64 (1): 202–8. doi:10.1158/0008-5472.CAN-03-2833. PMID 14729625.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhang H, Duan HO, Kirley SD, et al. (2006). "Aberrant splicing of cables gene, a CDK regulator, in human cancers". Cancer Biol. Ther. 4 (11): 1211–5. doi:10.4161/cbt.4.11.2085. PMID 16177568.
Nusbaum C, Zody MC, Borowsky ML, et al. (2005). "DNA sequence and analysis of human chromosome 18". Nature. 437 (7058): 551–5. doi:10.1038/nature03983. PMID 16177791.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Hirao N, Sato S, Gotoh T, et al. (2007). "NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation". FEBS Lett. 580 (27): 6464–70. doi:10.1016/j.febslet.2006.10.065. PMID 17101133. S2CID 20005197.

This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134508 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040957 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12477932-5] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[entrez-6] "Entrez Gene: CABLES1 Cdk5 and Abl enzyme substrate 1".

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References

External links

Further reading