FBXO6

FBXO6
Identifiers
Aliases	FBXO6, FBG2, FBS2, FBX6, Fbx6b, F-box protein 6
External IDs	OMIM: 605647; MGI: 1354743; HomoloGene: 9274; GeneCards: FBXO6; OMA:FBXO6 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	11,674,354 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	148,236,597 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; muscle of thigh; ; gastrocnemius muscle; ; bronchial epithelial cell; ; blood; ; right lobe of liver; ; olfactory zone of nasal mucosa; ; mucosa of ileum; ; right adrenal gland;
	Top expressed in
	urinary bladder; ; muscle of thigh; ; adrenal gland; ; muscle tissue; ; skeletal muscle tissue; ; quadriceps femoris muscle; ; placenta; ; white adipose tissue; ; lip; ; right kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquitin protein ligase activity; carbohydrate binding; ubiquitin-protein transferase activity; protein binding;
Cellular component	cytoplasm; SCF ubiquitin ligase complex; endoplasmic reticulum quality control compartment; cytosol;
Biological process	cellular response to DNA damage stimulus; DNA damage checkpoint signaling; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; response to unfolded protein; DNA repair; protein ubiquitination; proteolysis; ubiquitin-dependent ERAD pathway; glycoprotein catabolic process; protein polyubiquitination; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	26270
	50762
	ENSG00000116663
	ENSMUSG00000055401
	Q9NRD1
	Q9QZN4
	NM_018438
	NM_001163704; NM_001163705; NM_001163706; NM_001163707; NM_015797
	NP_060908
	NP_001157176; NP_001157177; NP_001157178; NP_001157179; NP_056612
	Wikidata
View/Edit Human	View/Edit Mouse

F-box only protein 6 is a protein that in humans is encoded by the FBXO6 gene.^[5]^[6]^[7]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116663 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055401 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
^ Ilyin GP, Rialland M, Pigeon C, Guguen-Guillouzo C (Nov 2000). "cDNA cloning and expression analysis of new members of the mammalian F-box protein family". Genomics. 67 (1): 40–7. doi:10.1006/geno.2000.6211. PMID 10945468.
^ ^a ^b "Entrez Gene: FBXO6 F-box protein 6".

Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Yoshida Y, Tokunaga F, Chiba T, et al. (2003). "Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains". J. Biol. Chem. 278 (44): 43877–84. doi:10.1074/jbc.M304157200. PMID 12939278.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ilyin GP, Sérandour AL, Pigeon C, et al. (2003). "A new subfamily of structurally related human F-box proteins". Gene. 296 (1–2): 11–20. doi:10.1016/S0378-1119(02)00867-3. PMID 12383498.
Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins". Curr. Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116663 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055401 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10531035-5] Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.

[pmid10945468-6] Ilyin GP, Rialland M, Pigeon C, Guguen-Guillouzo C (Nov 2000). "cDNA cloning and expression analysis of new members of the mammalian F-box protein family". Genomics. 67 (1): 40–7. doi:10.1006/geno.2000.6211. PMID 10945468.

[entrez-7] "Entrez Gene: FBXO6 F-box protein 6".

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References

Further reading