SPACA3

SPACA3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4YF2
Identifiers
Aliases	SPACA3, 1700025M08Rik, ALLP17, CT54, LYC3, LYZL3, SLLP1, LYZC, sperm acrosome associated 3
External IDs	OMIM: 612749; MGI: 1922872; HomoloGene: 18365; GeneCards: SPACA3; OMA:SPACA3 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	32,997,877 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	80,758,640 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; sperm; ; testicle; ; body of pancreas; ; gonad; ; mucosa of transverse colon; ; right coronary artery; ; tibial nerve; ; granulocyte;
	Top expressed in
	spermatid; ; seminiferous tubule; ; spermatocyte; ; lacrimal gland; ; morula; ; pancreas; ; cochlea; ; islet of Langerhans; ; foregut; ; stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; lysozyme activity;
Cellular component	integral component of membrane; extracellular region; acrosomal vesicle; secretory granule; membrane; cytoplasmic vesicle; extracellular space; acrosomal membrane; acrosomal matrix;
Biological process	monocyte activation; cell wall macromolecule catabolic process; fertilization; positive regulation of phagocytosis; response to virus; positive regulation of macrophage activation; sperm-egg recognition; defense response to Gram-positive bacterium; peptidoglycan catabolic process; defense response to Gram-negative bacterium; fusion of sperm to egg plasma membrane involved in single fertilization;
	Sources:Amigo / QuickGO
Orthologs
	124912
	75622
	ENSG00000141316
	ENSMUSG00000053184
	Q8IXA5
	Q9D9X8
	NM_173847; NM_001317225; NM_001317226
	NM_029367; NM_001359183
	NP_001304154; NP_001304155; NP_776246
	NP_083643; NP_001346112
	Wikidata
View/Edit Human	View/Edit Mouse

Sperm acrosome membrane-associated protein 3 is a protein that in humans is encoded by the SPACA3 gene. It may be involved in adhesion to the egg before the egg is fertilized.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141316 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053184 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mandal A, Klotz KL, Shetty J, Jayes FL, Wolkowicz MJ, Bolling LC, Coonrod SA, Black MB, Diekman AB, Haystead TA, Flickinger CJ, Herr JC (Apr 2003). "SLLP1, a unique, intra-acrosomal, non-bacteriolytic, c lysozyme-like protein of human spermatozoa". Biol Reprod. 68 (5): 1525–37. doi:10.1095/biolreprod.102.010108. PMID 12606493.
^ "Entrez Gene: SPACA3 sperm acrosome associated 3".

Niyonsaba F, Ogawa H (2006). "Protective roles of the skin against infection: implication of naturally occurring human antimicrobial agents beta-defensins, cathelicidin LL-37 and lysozyme". J. Dermatol. Sci. 40 (3): 157–68. doi:10.1016/j.jdermsci.2005.07.009. PMID 16150577.
Cramer EM, Breton-Gorius J (1987). "Ultrastructural localization of lysozyme in human neutrophils by immunogold". J. Leukoc. Biol. 41 (3): 242–7. doi:10.1002/jlb.41.3.242. PMID 3470418. S2CID 32012371.
Welsh IR, Spitznagel JK (1973). "Distribution of lysosomal enzymes, cationic proteins, and bactericidal substances in subcellular fractions of human polymorphonuclear leukocytes". Infect. Immun. 4 (2): 97–102. doi:10.1128/IAI.4.2.97-102.1971. PMC 416271. PMID 5154881.
Ibrahim HR, Matsuzaki T, Aoki T (2001). "Genetic evidence that antibacterial activity of lysozyme is independent of its catalytic function". FEBS Lett. 506 (1): 27–32. doi:10.1016/S0014-5793(01)02872-1. PMID 11591365. S2CID 21593262.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Wang Z, Zhang Y, Mandal A, et al. (2005). "The spermatozoa protein, SLLP1, is a novel cancer-testis antigen in hematologic malignancies". Clin. Cancer Res. 10 (19): 6544–50. doi:10.1158/1078-0432.CCR-04-0911. PMID 15475442.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhang K, Gao R, Zhang H, et al. (2006). "Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family". Biol. Reprod. 73 (5): 1064–71. doi:10.1095/biolreprod.105.041889. PMID 16014814. S2CID 21603980.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141316 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000053184 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12606493-5] Mandal A, Klotz KL, Shetty J, Jayes FL, Wolkowicz MJ, Bolling LC, Coonrod SA, Black MB, Diekman AB, Haystead TA, Flickinger CJ, Herr JC (Apr 2003). "SLLP1, a unique, intra-acrosomal, non-bacteriolytic, c lysozyme-like protein of human spermatozoa". Biol Reprod. 68 (5): 1525–37. doi:10.1095/biolreprod.102.010108. PMID 12606493.

[entrez-6] "Entrez Gene: SPACA3 sperm acrosome associated 3".

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References

Further reading