FRMD6

FRMD6
Identifiers
Aliases	FRMD6, C14orf31, EX1, Willin, c14_5320, FERM domain containing 6
External IDs	OMIM: 614555; MGI: 2442579; HomoloGene: 12449; GeneCards: FRMD6; OMA:FRMD6 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	51,730,727 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	70,949,008 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; cartilage tissue; ; tibia; ; tail of epididymis; ; stromal cell of endometrium; ; epithelium of lactiferous gland; ; lactiferous duct; ; oral cavity; ; skin of thigh; ; skin of hip;
	Top expressed in
	calvaria; ; skin of external ear; ; hair follicle; ; ankle joint; ; body of femur; ; skin of back; ; corneal stroma; ; lip; ; conjunctival fornix; ; sciatic nerve;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; structural constituent of cytoskeleton;
Cellular component	apical junction complex; plasma membrane; membrane; cytoplasm; cytoskeleton;
Biological process	regulation of actin filament-based process; apical constriction; actomyosin structure organization;
	Sources:Amigo / QuickGO
Orthologs
	122786
	319710
	ENSG00000139926
	ENSMUSG00000048285
	Q96NE9
	Q8C0V9
	NM_001042481; NM_001267046; NM_001267047; NM_152330
	NM_028127
	NP_001035946; NP_001253975; NP_001253976; NP_689543
	NP_082403
	Wikidata
View/Edit Human	View/Edit Mouse

FERM domain-containing protein 6 is a protein that in humans is encoded by the FRMD6 gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000139926 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048285 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: FRMD6 FERM domain containing 6".

Kronenberg NM, Tilston-Lunel A, Thompson FE, Chen D, Yu W, Dholakia K, Gather MC, Gunn-Moore FJ (2020). "Willin/FRMD6 Influences Mechanical Phenotype and Neuronal Differentiation in Mammalian Cells by Regulating ERK1/2 Activity". Frontiers in Cellular Neuroscience. 14: 552213. doi:10.3389/fncel.2020.552213. PMC 7498650. PMID 33088261.
Moleirinho S, Patrick C, Tilston-Lünel AM, Higginson JR, Angus L, Antkowiak M, Barnett SC, Prystowsky MB, Reynolds PA, Gunn-Moore FJ (2013). "Willin, an Upstream Component of the Hippo Signaling Pathway, Orchestrates Mammalian Peripheral Nerve Fibroblasts". PLOS ONE. 8 (4): e60028. Bibcode:2013PLoSO...860028M. doi:10.1371/journal.pone.0060028. PMC 3620498. PMID 23593160.
Angus L, Moleirinho S, Herron L, Sinha A, Zhang X, Niestrata M, Dholakia K, Prystowsky MB, Harvey KF, Reynolds PA, Gunn-Moore FJ (January 2012). "Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP". Oncogene. 31 (2): 238–50. doi:10.1038/onc.2011.224. hdl:10023/2489. PMID 21666719.
Madan R, Brandwein-Gensler M, Schlecht NF, Elias K, Gorbovitsky E, Belbin TJ, Mahmood R, Breining D, Qian H, Childs G, Locker J, Smith R, Haigentz M, Gunn-Moore F, Prystowsky MB (November 2006). "Differential tissue and subcellular expressionof ERM proteins in normal and malignant tissues: cytoplasmic ezrin expression has prognostic significance for head and neck squamous cell carcinoma". Head & Neck. 28 (11): 1018–27. doi:10.1002/hed.20435. PMID 16783828. S2CID 32305188.
Hamaratoglu F, Willecke M, Kango-Singh M, Nolo R, Hyun E, Tao C, Jafar-Nejad H, Halder G (January 2006). "The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis". Nature Cell Biology. 8 (1): 27–36. doi:10.1038/ncb1339. PMID 16341207. S2CID 15468669.
Gunn-Moore FJ, Welsh GI, Herron LR, Brannigan F, Venkateswarlu K, Gillespie S, Brandwein-Gensler M, Madan R, Tavaré JM, Brophy PJ, Prystowsky MB, Guild S (September 2005). "A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'" (PDF). FEBS Letters. 579 (22): 5089–94. doi:10.1016/j.febslet.2005.07.097. PMID 16137681.
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (August 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000139926 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048285 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FRMD6 FERM domain containing 6".

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References

Further reading