CCDC80

CCDC80
Identifiers
Aliases	CCDC80, DRO1, SSG1, URB, okuribin, coiled-coil domain containing 80, CL2, LINC01279
External IDs	OMIM: 608298; MGI: 1915146; HomoloGene: 12206; GeneCards: CCDC80; OMA:CCDC80 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	112,649,530 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	44,948,440 bp
RNA expression pattern
	Top expressed in
	parietal pleura; ; tendon of biceps brachii; ; smooth muscle tissue; ; skin of arm; ; gallbladder; ; skin of hip; ; vena cava; ; saphenous vein; ; stromal cell of endometrium; ; tibia;
	Top expressed in
	calvaria; ; stroma of bone marrow; ; white adipose tissue; ; ankle; ; skin of external ear; ; body of femur; ; semi-lunar valve; ; efferent ductule; ; aortic valve; ; umbilical cord;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	fibronectin binding; glycosaminoglycan binding; heparin binding;
Cellular component	extracellular region; basement membrane; interstitial matrix; extracellular matrix;
Biological process	extracellular matrix organization; positive regulation of cell-substrate adhesion; response to bacterium;
	Sources:Amigo / QuickGO
Orthologs
	151887
	67896
	ENSG00000091986
	ENSMUSG00000022665
	Q76M96
	Q8R2G6
	NM_199512; NM_199511; NM_178274
	NM_026439
	NP_955805; NP_955806
	NP_080715
	Wikidata
View/Edit Human	View/Edit Mouse

Coiled-coil domain-containing protein 80 is a protein that in humans is encoded by the CCDC80 gene.^[5]^[6]^[7] Bioinformatics analysis suggests the CCDC80 protein is a peroxiredoxin.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000091986 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022665 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bonaldo MF, Lennon G, Soares MB (May 1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
^ Liu Y, Monticone M, Tonachini L, Mastrogiacomo M, Marigo V, Cancedda R, Castagnola P (Aug 2004). "URB expression in human bone marrow stromal cells and during mouse development". Biochem Biophys Res Commun. 322 (2): 497–507. doi:10.1016/j.bbrc.2004.07.161. PMID 15325258.
^ "Entrez Gene: CCDC80 coiled-coil domain containing 80".
^ Pawłowski K, Muszewska A, Lenart A, et al. (2010). "A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins". BMC Genomics. 11: 590. doi:10.1186/1471-2164-11-590. PMC 3091736. PMID 20964819.{{cite journal}}: CS1 maint: unflagged free DOI (link)

External links

Human CCDC80 genome location and CCDC80 gene details page in the UCSC Genome Browser.

Okada T, Nishizawa H, Kurata A, et al. (2008). "URB is abundantly expressed in adipose tissue and dysregulated in obesity". Biochem. Biophys. Res. Commun. 367 (2): 370–6. doi:10.1016/j.bbrc.2007.12.164. PMID 18178152.
Cha SY, Sung YK, Im S, et al. (2005). "URB expression in human dermal papilla cells". J. Dermatol. Sci. 39 (2): 128–30. doi:10.1016/j.jdermsci.2005.05.005. PMID 15998583.
Bommer GT, Jäger C, Dürr EM, et al. (2005). "DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells". J. Biol. Chem. 280 (9): 7962–75. doi:10.1074/jbc.M412593200. PMID 15563452.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Aoki K, Sun YJ, Aoki S, et al. (2002). "Cloning, expression, and mapping of a gene that is upregulated in adipose tissue of mice deficient in bombesin receptor subtype-3". Biochem. Biophys. Res. Commun. 290 (4): 1282–8. doi:10.1006/bbrc.2002.6337. PMID 11812002.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000091986 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022665 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8889548-5] Bonaldo MF, Lennon G, Soares MB (May 1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

[pmid15325258-6] Liu Y, Monticone M, Tonachini L, Mastrogiacomo M, Marigo V, Cancedda R, Castagnola P (Aug 2004). "URB expression in human bone marrow stromal cells and during mouse development". Biochem Biophys Res Commun. 322 (2): 497–507. doi:10.1016/j.bbrc.2004.07.161. PMID 15325258.

[entrez-7] "Entrez Gene: CCDC80 coiled-coil domain containing 80".

[pmid20964819-8] Pawłowski K, Muszewska A, Lenart A, et al. (2010). "A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins". BMC Genomics. 11: 590. doi:10.1186/1471-2164-11-590. PMC 3091736. PMID 20964819.{{cite journal}}: CS1 maint: unflagged free DOI (link)

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References

External links

Further reading