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Centrin 1

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CETN1
Identifiers
AliasesCETN1, CEN1, CETN, centrin 1
External IDsOMIM: 603187; MGI: 1347086; HomoloGene: 105668; GeneCards: CETN1; OMA:CETN1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004066

NM_007593

RefSeq (protein)

NP_004057

NP_031619

Location (UCSC)Chr 18: 0.58 – 0.58 MbChr 18: 9.62 – 9.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centrin-1 is a protein that in humans is encoded by the CETN1 gene.[5][6] It belongs to the centrin family of proteins.

The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This encoded protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177143Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050996Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Errabolu R, Sanders MA, Salisbury JL (Jun 1994). "Cloning of a cDNA encoding human centrin, an EF-hand protein of centrosomes and mitotic spindle poles". J Cell Sci. 107. ( Pt 1): 9–16. doi:10.1242/jcs.107.1.9. PMID 8175926.
  6. ^ a b "Entrez Gene: CETN1 centrin, EF-hand protein, 1".

Further reading