Formin-like protein 3 (FMNL3), also known as WW domain-binding protein 3 (WBP-3), is a protein that in humans is encoded by the FMNL3gene.[5][6]
Function
The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described.[5] The C-terminus has been shown to accelerate actin polymerization activity of this protein through its WH2-like motif.[7] FMNL3 has been crystallized in complex with actin providing insight into the mechanism of formin-mediated actin nucleation.[8]
^Katoh M, Katoh M (May 2003). "Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico". International Journal of Oncology. 22 (5): 1161–8. doi:10.3892/ijo.22.5.1161. PMID12684686.