FMNL2

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FMNL2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FMNL2, FHOD2, formin like 2
External IDs MGI: 1918659 HomoloGene: 70871 GeneCards: FMNL2
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001004417
NM_001004421
NM_001004422
NM_052905

NM_172409

RefSeq (protein)

NP_443137

NP_765997.2
NP_765997

Location (UCSC) Chr 2: 152.34 – 152.65 Mb Chr 2: 52.86 – 53.13 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Formin-like protein 2 is a protein that in humans is encoded by the FMNL2 gene.[3][4]

Expression[edit]

Alternatively spliced transcript variants of the FMNL2 gene encoding different isoforms have been described.[3] The full length FMNL2 (FRL3) protein (1092 amino acids-NCBI Reference Sequence: NP_443137.2[5]) is regulated through autoinhibition, and may become activated through Rho proteins.[6] The FMNL2 gene is expressed in multiple human tissues.[7]

Function[edit]

Formin-like protein 2 is a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity.[3]

Clinical significance[edit]

FMNL2 expression is considerably higher in colorectal cancer tumors compared to normal tissue.[8]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b c "Entrez Gene: FMNL2 formin-like 2". 
  4. ^ Katoh M, Katoh M (May 2003). "Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico". Int. J. Oncol. 22 (5): 1161–8. doi:10.3892/ijo.22.5.1161. PMID 12684686. 
  5. ^ "formin-like protein 2 [Homo sapiens]" (NCBI Reference Sequence: NP_443137.2). National Center for Biotechnology Information, U.S. National Library of Medicine. 
  6. ^ Kitzing TM, Wang Y, Pertz O, Copeland JW, Grosse R (April 2010). "Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC". Oncogene. 29 (16): 2441–8. doi:10.1038/onc.2009.515. PMID 20101212. 
  7. ^ Gardberg M, Talvinen K, Kaipio K, Iljin K, Kampf C, Uhlen M, Carpén O (2010). "Characterization of Diaphanous-related formin FMNL2 in human tissues". BMC Cell Biol. 11: 55. doi:10.1186/1471-2121-11-55. PMC 2912821Freely accessible. PMID 20633255. 
  8. ^ Zhu XL, Liang L, Ding YQ (November 2008). "Overexpression of FMNL2 is closely related to metastasis of colorectal cancer". Int J Colorectal Dis. 23 (11): 1041–7. doi:10.1007/s00384-008-0520-2. PMID 18665374.