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The route travels generally in a southeast to northwest direction, starting unsigned on Brown Road in western Greenville County. The highway almost immediately comes to an interchange with Southern Connector Toll Road (Interstate 185 or I-185). The two-lane road crosses over the Saluda River into Anderson County where it then meets I-85 at exit 40. From I-85 until the terminus with U.S. Highway 123 (US 123) in Pickens County, SC 153 is a four-lane road that is relatively developed with commercial land uses.[2]