UTF1

UTF1
Identifiers
Aliases	UTF1, undifferentiated embryonic cell transcription factor 1
External IDs	OMIM: 604130; MGI: 1276125; HomoloGene: 48226; GeneCards: UTF1; OMA:UTF1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	133,231,558 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	139,525,025 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; right testis; ; left testis; ; granulocyte; ; monocyte; ; skin of thigh; ; right uterine tube; ; blood; ; ovary;
	Top expressed in
	embryo; ; epiblast; ; Gonadal ridge; ; chorion; ; blastocyst; ; embryo; ; morula; ; yolk sac; ; placenta; ; inner cell mass;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription coactivator activity; HMG box domain binding; protein binding;
Cellular component	nucleus;
Biological process	regulation of transcription by RNA polymerase II; male gonad development; regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	8433
	22286
	ENSG00000171794
	ENSMUSG00000047751
	Q5T230
	Q6J1H4
	NM_003577
	NM_009482
	NP_003568
	NP_033508
	Wikidata
View/Edit Human	View/Edit Mouse

Undifferentiated embryonic cell transcription factor 1 is a protein in humans that is encoded by the UTF1 gene. ^[5] UTF1, first reported in 1998, is expressed in pluripotent cells including embryonic stem cells and embryonic carcinoma cells.^[6] Its expression is rapidly reduced upon differentiation. UTF1 protein is localized to the cell nucleus, where it functions to regulate the pluripotent chromatin state and buffer mRNA levels by promoting degradation of mRNA.^[7]

Aberrant expression of UTF1 has also been reported in cervical cancer cells, where the UTF1 gene promoter loses methylation and becomes abnormally expressed compared to normal cervical cells.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171794 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047751 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Undifferentiated embryonic cell transcription factor 1". Retrieved 2013-05-30.
^ Okuda A; Fukushima A; Nishimoto M; Orimo A; Yamagishi T; Nabeshima Y; Kuro-o M; Nabeshima Yi; Boon K; Keaveney M; Stunnenberg HG; Muramatsu M. (April 1998). "UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells". EMBO J. 17 (7): 2019–32. doi:10.1093/emboj/17.7.2019. PMC 1170547. PMID 9524124.
^ Jia J, Zheng X, Hu G, Cui K, Zhang J, Zhang A, Jiang H, Lu B, Yates J, Liu C, Zhao K, Zheng Y (October 2012). "Regulation of pluripotency and self- renewal of ESCs through epigenetic-threshold modulation and mRNA pruning". Cell. 151 (3): 576–89. doi:10.1016/j.cell.2012.09.023. PMC 3575637. PMID 23101626.
^ Guenin S, Mouallif M, Deplus R, Lampe X, Krusy N, Calonne E, Delbecque K, Kridelka F, Fuks F, Ennaji MM, Delvenne P (August 2012). "Aberrant promoter methylation and expression of UTF1 during cervical carcinogenesis". PLOS ONE. 7 (8): e42704. doi:10.1371/journal.pone.0042704. PMC 3411846. PMID 22880087.{{cite journal}}: CS1 maint: unflagged free DOI (link)

References

Further reading