This is an old revision of this page, as edited by Boghog(talk | contribs) at 09:16, 27 November 2018(replace infobox protein with the more detailed infobox gene). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.
Revision as of 09:16, 27 November 2018 by Boghog(talk | contribs)(replace infobox protein with the more detailed infobox gene)
4-Hydroxy-2-oxoglutarate aldolase, mitochondrial (HOGA1) also known as dihydrodipicolinate synthase-like (DHDPSL) is an enzyme that in humans is encoded by the HOGA1 gene. The protein is one of the enzymes (4-hydroxy-2-oxoglutarate aldolase) involved in metabolism of hydroxyproline to glyoxylate. The enzyme overactivity can form excessive glyoxylate from hydroxyproline. Glyoxylate is catabolised to oxalate, resulting in excess excretion of oxalate in urine, predisposing to oxalate stone; a condition known as primary hyperoxaluria type III.[5]