Zinc transporter ZIP12

SLC39A12
Identifiers
Aliases	SLC39A12, LZT-Hs8, ZIP-12, bA570F3.1, solute carrier family 39 member 12, ZIP12
External IDs	OMIM: 608734; MGI: 2139274; HomoloGene: 17654; GeneCards: SLC39A12; OMA:SLC39A12 - orthologs
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	14,499,788 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; secondary oocyte; ; cerebellar vermis; ; external globus pallidus; ; putamen; ; entorhinal cortex; ; Brodmann area 9; ; amygdala; ; hippocampus proper; ; superior frontal gyrus;
	Top expressed in
	Epithelium of choroid plexus; ; lumbar subsegment of spinal cord; ; deep cerebellar nuclei; ; suprachiasmatic nucleus; ; medial vestibular nucleus; ; retinal pigment epithelium; ; dorsal tegmental nucleus; ; inferior colliculus; ; superior colliculus; ; mammillary body;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion transmembrane transporter activity; zinc ion transmembrane transporter activity;
Cellular component	perinuclear region of cytoplasm; integral component of membrane; extracellular vesicle; plasma membrane; membrane; integral component of plasma membrane;
Biological process	metal ion transport; zinc ion transport; ion transport; regulation of neuron projection development; regulation of microtubule polymerization; transmembrane transport; cellular zinc ion homeostasis; signal transduction; zinc ion import across plasma membrane; transport;
	Sources:Amigo / QuickGO
Orthologs
	221074
	277468
	n/a
	ENSMUSG00000036949
	Q504Y0
	Q5FWH7
	NM_152725; NM_001145195; NM_001282733; NM_001282734
	NM_001012305
	NP_001138667; NP_001269662; NP_001269663; NP_689938
	NP_001012305
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 39 member 12 is a protein that in humans is encoded by the SLC39A12 gene. ^[4]

Function

Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A12 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036949 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Solute carrier family 39 member 12". Retrieved 2017-06-15.

Bly M (2006). "Examination of the zinc transporter gene, SLC39A12". Schizophr. Res. 81 (2–3): 321–2. doi:10.1016/j.schres.2005.07.039. PMID 16311021.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A (2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.
Wang L, McDonnell SK, Hebbring SJ, Cunningham JM, St Sauver J, Cerhan JR, Isaya G, Schaid DJ, Thibodeau SN (2008). "Polymorphisms in mitochondrial genes and prostate cancer risk". Cancer Epidemiol. Biomarkers Prev. 17 (12): 3558–66. doi:10.1158/1055-9965.EPI-08-0434. PMC 2750891. PMID 19064571.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000036949 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: Solute carrier family 39 member 12". Retrieved 2017-06-15.

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Function

References

Further reading