Response element

Response elements are short sequences of DNA within a gene promoter or enhancer region that are able to bind specific transcription factors and regulate transcription of genes.

Under conditions of stress, a transcription activator protein binds to the response element and stimulates transcription. If the same response element sequence is located in the control regions of different genes, then these genes will be activated by the same stimuli, thus producing a coordinated response.

Examples

Examples of response elements include:

• cAMP response element (CRE)
• B recognition element
• AhR-, dioxin- or xenobiotic- responsive element
• Hypoxia-responsive elements
• Hormone response element : 1- estrogen response elements (EREs) and 2- androgen response elements (AREs)
• Serum response element (SRE)
• Retinoic acid response elements (RAREs)
• Peroxisome proliferator hormone response elements (PPREs)
• Metal-responsive element (MRE)
• DNA damage response element (DRE)
• IFN-stimulated response elements (ISREs)
• ROR-response element
• Glucocorticoid response element (GRE)
• Calcium-response element CaRE1
• Antioxidant response element (ARE)
• p53 response element
• Thyroid hormone response element
• Growth hormone response element (GHRE)
• Sterol response element
• Polycomb Response Elements (PREs)
• Vitamin D response element (VDRE)
• Rev response element (RRE)

External links

• response+element at the U.S. National Library of Medicine Medical Subject Headings (MeSH)