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From Wikipedia, the free encyclopedia
Available structures
PDBOrtholog search: PDBe RCSB
AliasesHDAC1, GON-10, HD1, RPD3, RPD3L1, histone deacetylase 1, KDAC1
External IDsOMIM: 601241; MGI: 108086; HomoloGene: 68426; GeneCards: HDAC1; OMA:HDAC1 - orthologs
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 1: 32.29 – 32.33 MbChr 4: 129.41 – 129.44 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene.[5]


Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.[6]


HDAC1 has been shown to interact with:

See also[edit]


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