ELOVL4

ELOVL4
Identifiers
Aliases	ELOVL4, ADMD, CT118, ISQMR, SCA34, STGD2, STGD3, ELOVL fatty acid elongase 4
External IDs	OMIM: 605512; MGI: 1933331; HomoloGene: 41488; GeneCards: ELOVL4; OMA:ELOVL4 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	79,947,553 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	83,688,330 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; skin of arm; ; vulva; ; thymus; ; cerebellar vermis; ; human penis; ; skin of abdomen; ; secondary oocyte; ; postcentral gyrus; ; orbitofrontal cortex;
	Top expressed in
	skin of external ear; ; lip; ; skin of back; ; skin of abdomen; ; neural layer of retina; ; esophagus; ; retinal pigment epithelium; ; belly cord; ; pontine nuclei; ; anterior horn of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; G protein-coupled photoreceptor activity; protein binding; 3-oxo-arachidoyl-CoA synthase activity; 3-oxo-cerotoyl-CoA synthase activity; 3-oxo-lignoceronyl-CoA synthase activity; fatty acid elongase activity; very-long-chain 3-ketoacyl-CoA synthase activity;
Cellular component	integral component of membrane; integral component of endoplasmic reticulum membrane; endoplasmic reticulum membrane; endoplasmic reticulum; membrane;
Biological process	fatty acid biosynthetic process; fatty acid metabolic process; lipid metabolism; fatty acid elongation, saturated fatty acid; very long-chain fatty acid biosynthetic process; detection of visible light; sphingolipid biosynthetic process; fatty acid elongation, monounsaturated fatty acid; fatty acid elongation, polyunsaturated fatty acid; unsaturated fatty acid biosynthetic process; long-chain fatty-acyl-CoA biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	6785
	83603
	ENSG00000118402
	ENSMUSG00000032262
	Q9GZR5
	Q9EQC4
	NM_022726
	NM_148941
	NP_073563
	NP_683743
	Wikidata
View/Edit Human	View/Edit Mouse

Elongation of very long chain fatty acids protein 4 is a protein that in humans is encoded by the ELOVL4 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000118402 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032262 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhang K, Kniazeva M, Han M, Li W, Yu Z, Yang Z, Li Y, Metzker ML, Allikmets R, Zack DJ, Kakuk LE, Lagali PS, Wong PW, MacDonald IM, Sieving PA, Figueroa DJ, Austin CP, Gould RJ, Ayyagari R, Petrukhin K (Jan 2001). "A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy". Nat Genet. 27 (1): 89–93. doi:10.1038/83817. PMID 11138005.
^ "Entrez Gene: ELOVL4 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4".

Zhang K; Bither PP; Park R; et al. (1994). "A dominant Stargardt's macular dystrophy locus maps to chromosome 13q34". Arch. Ophthalmol. 112 (6): 759–64. doi:10.1001/archopht.1994.01090180057035. PMID 8002833. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Stone EM; Nichols BE; Kimura AE; et al. (1994). "Clinical features of a Stargardt-like dominant progressive macular dystrophy with genetic linkage to chromosome 6q". Arch. Ophthalmol. 112 (6): 765–72. doi:10.1001/archopht.1994.01090180063036. PMID 8002834. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Edwards AO; Miedziak A; Vrabec T; et al. (1999). "Autosomal dominant Stargardt-like macular dystrophy: I. Clinical characterization, longitudinal follow-up, and evidence for a common ancestry in families linked to chromosome 6q14". Am. J. Ophthalmol. 127 (4): 426–35. doi:10.1016/S0002-9394(98)00331-6. PMID 10218695. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Li Y; Marcos I; Borrego S; et al. (2001). "Evaluation of the ELOVL4 gene in families with retinitis pigmentosa linked to the RP25 locus". J. Med. Genet. 38 (7): 478–80. doi:10.1136/jmg.38.7.478. PMC 1757187. PMID 11474659. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Edwards AO, Donoso LA, Ritter R (2001). "A novel gene for autosomal dominant Stargardt-like macular dystrophy with homology to the SUR4 protein family". Invest. Ophthalmol. Vis. Sci. 42 (11): 2652–63. PMID 11581213.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Rivolta C; Ayyagari R; Sieving PA; et al. (2003). "Evaluation of the ELOVL4 gene in patients with autosomal recessive retinitis pigmentosa and Leber congenital amaurosis". Mol. Vis. 9: 49–51. PMID 12592226. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Lagali PS; Liu J; Ambasudhan R; et al. (2003). "Evolutionarily conserved ELOVL4 gene expression in the vertebrate retina". Invest. Ophthalmol. Vis. Sci. 44 (7): 2841–50. doi:10.1167/iovs.02-0991. PMID 12824221. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Vrabec TR; Tantri A; Edwards A; et al. (2003). "Autosomal dominant Stargardt-like macular dystrophy: identification of a new family with a mutation in the ELOVL4 gene". Am. J. Ophthalmol. 136 (3): 542–5. doi:10.1016/S0002-9394(03)00227-7. PMID 12967813. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Mungall AJ; Palmer SA; Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Ambasudhan R; Wang X; Jablonski MM; et al. (2004). "Atrophic macular degeneration mutations in ELOVL4 result in the intracellular misrouting of the protein". Genomics. 83 (4): 615–25. doi:10.1016/j.ygeno.2003.10.004. PMID 15028284. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Grayson C, Molday RS (2005). "Dominant negative mechanism underlies autosomal dominant Stargardt-like macular dystrophy linked to mutations in ELOVL4". J. Biol. Chem. 280 (37): 32521–30. doi:10.1074/jbc.M503411200. PMID 16036915.
Lai Z; Zhang XN; Zhou W; et al. (2006). "Evaluation of the ELOVL4 gene in a Chinese family with autosomal dominant STGD3-like macular dystrophy". J. Cell. Mol. Med. 9 (4): 961–5. doi:10.1111/j.1582-4934.2005.tb00392.x. PMC 6740257. PMID 16364203. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Hubbard AF; Askew EW; Singh N; et al. (2006). "Association of adipose and red blood cell lipids with severity of dominant Stargardt macular dystrophy (STGD3) secondary to an ELOVL4 mutation". Arch. Ophthalmol. 124 (2): 257–63. doi:10.1001/archopht.124.2.257. PMID 16476896. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Seitsonen S; Lemmelä S; Holopainen J; et al. (2006). "Analysis of variants in the complement factor H, the elongation of very long chain fatty acids-like 4 and the hemicentin 1 genes of age-related macular degeneration in the Finnish population". Mol. Vis. 12: 796–801. PMID 16885922. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
McMahon A; Butovich IA; Mata NL; et al. (2007). "Retinal pathology and skin barrier defect in mice carrying a Stargardt disease-3 mutation in elongase of very long chain fatty acids-4". Mol. Vis. 13: 258–72. PMC 2633486. PMID 17356513. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)CS1 maint: numeric names: authors list (link)

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000118402 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032262 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11138005-5] Zhang K, Kniazeva M, Han M, Li W, Yu Z, Yang Z, Li Y, Metzker ML, Allikmets R, Zack DJ, Kakuk LE, Lagali PS, Wong PW, MacDonald IM, Sieving PA, Figueroa DJ, Austin CP, Gould RJ, Ayyagari R, Petrukhin K (Jan 2001). "A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy". Nat Genet. 27 (1): 89–93. doi:10.1038/83817. PMID 11138005.

[entrez-6] "Entrez Gene: ELOVL4 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4".

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ELOVL4

See also

References

Further reading