MAK (gene)

MAK
Identifiers
Aliases	MAK, RP62, dJ417M14.2, male germ cell associated kinase
External IDs	OMIM: 154235; MGI: 96913; HomoloGene: 31344; GeneCards: MAK; OMA:MAK - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p24.2 Start 10,762,723 bp End 10,838,553 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13 A3.3|13 20.25 cM Start 41,178,484 bp End 41,233,182 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm Epithelium of choroid plexus bronchial epithelial cell right uterine tube testicle epithelium of nasopharynx blood mucosa of paranasal sinus left testis right testis Top expressed in neural layer of retina spermatid seminiferous tubule spermatocyte epithelium of lens retinal pigment epithelium outer nuclear layer Epithelium of choroid plexus right lung lobe respiratory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding transcription coactivator activity kinase activity protein binding ATP binding metal ion binding protein serine/threonine kinase activity Cellular component centrosome cell projection photoreceptor inner segment spindle photoreceptor outer segment microtubule organizing center midbody mitotic spindle cytoskeleton nucleus cytoplasm cilium axoneme motile cilium photoreceptor connecting cilium ciliary tip Biological process cell differentiation regulation of transcription, DNA-templated phosphorylation transcription, DNA-templated multicellular organism development protein phosphorylation spermatogenesis protein autophosphorylation regulation of gene expression intracellular signal transduction intraciliary transport cilium assembly photoreceptor cell maintenance negative regulation of non-motile cilium assembly positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4117 17152 Ensembl ENSG00000111837 ENSMUSG00000021363 UniProt P20794 Q04859 RefSeq (mRNA) NM_001242385 NM_001242957 NM_005906 NM_001377262 NM_001145802 NM_001145803 NM_008547 RefSeq (protein) NP_001229314 NP_001229886 NP_005897 NP_001364191 NP_001139274 NP_001139275 NP_032573 Location (UCSC) Chr 6: 10.76 – 10.84 Mb Chr 13: 41.18 – 41.23 Mb PubMed search
Wikidata
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Serine/threonine-protein kinase MAK is an enzyme that in humans is encoded by the MAK gene.

The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized.

Further reading

• Koji T, Jinno A, Matsushime H, et al. (1993). "In situ localization of male germ cell-associated kinase (mak) mRNA in adult mouse testis: specific expression in germ cells at stages around meiotic cell division". Cell Biochem. Funct. 10 (4): 273–9. doi:10.1002/cbf.290100411. PMID 1473268.
• Matsushime H, Jinno A, Takagi N, Shibuya M (1990). "A novel mammalian protein kinase gene (mak) is highly expressed in testicular germ cells at and after meiosis". Mol. Cell. Biol. 10 (5): 2261–8. doi:10.1128/MCB.10.5.2261. PMC 360573. PMID 2183027.
• Taketo M, Jinno A, Yamaguchi S, et al. (1994). "Mouse Mak gene for male germ cell-associated kinase maps to chromosome 13". Genomics. 19 (2): 397–8. doi:10.1006/geno.1994.1082. PMID 8188277.
• Jinno A, Tanaka K, Matsushime H, et al. (1993). "Testis-specific mak protein kinase is expressed specifically in the meiotic phase in spermatogenesis and is associated with a 210-kilodalton cellular phosphoprotein". Mol. Cell. Biol. 13 (7): 4146–56. doi:10.1128/MCB.13.7.4146. PMC 359964. PMID 8321219.
• Bladt F, Birchmeier C (1993). "Characterization and expression analysis of the murine rck gene: a protein kinase with a potential function in sensory cells". Differentiation. 53 (2): 115–22. doi:10.1111/j.1432-0436.1993.tb00651.x. PMID 8359591.
• Xia L, Robinson D, Ma AH, et al. (2002). "Identification of human male germ cell-associated kinase, a kinase transcriptionally activated by androgen in prostate cancer cells". J. Biol. Chem. 277 (38): 35422–33. doi:10.1074/jbc.M203940200. PMID 12084720.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Fu Z, Larson KA, Chitta RK, et al. (2007). "Identification of Yin-Yang Regulators and a Phosphorylation Consensus for Male Germ Cell-Associated Kinase (MAK)-Related Kinase". Mol. Cell. Biol. 26 (22): 8639–54. doi:10.1128/MCB.00816-06. PMC 1636783. PMID 16954377.