Kinetochore protein Nuf2 is a protein that in humans is encoded by the NUF2gene.[5][6][7]
This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation.
The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described.[7]
^Nabetani A, Koujin T, Tsutsumi C, Haraguchi T, Hiraoka Y (Oct 2001). "A conserved protein, Nuf2, is implicated in connecting the centromere to the spindle during chromosome segregation: a link between the kinetochore function and the spindle checkpoint". Chromosoma. 110 (5): 322–34. doi:10.1007/s004120100153. PMID11685532.
DeLuca JG, Howell BJ, Canman JC, et al. (2004). "Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores". Curr. Biol. 13 (23): 2103–9. doi:10.1016/j.cub.2003.10.056. PMID14654001.
Joseph J, Liu ST, Jablonski SA, et al. (2004). "The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo". Curr. Biol. 14 (7): 611–7. doi:10.1016/j.cub.2004.03.031. PMID15062103.
Stucke VM, Baumann C, Nigg EA (2005). "Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1". Chromosoma. 113 (1): 1–15. doi:10.1007/s00412-004-0288-2. PMID15235793.
Meraldi P, Draviam VM, Sorger PK (2004). "Timing and checkpoints in the regulation of mitotic progression". Dev. Cell. 7 (1): 45–60. doi:10.1016/j.devcel.2004.06.006. PMID15239953.