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NKRF (gene)

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NKRF
Identifiers
AliasesNKRF, ITBA4, NRF, NFKB repressing factor
External IDsOMIM: 300440; MGI: 1924536; HomoloGene: 84816; GeneCards: NKRF; OMA:NKRF - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001173487
NM_001173488
NM_017544

NM_029891

RefSeq (protein)

NP_060014

NP_084167

Location (UCSC)Chr X: 119.59 – 119.61 MbChr X: 36.15 – 36.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

NF-kappa-B-repressing factor is a protein that in humans is encoded by the NKRF gene.[5][6]

This gene encodes a transcription factor that interacts with specific negative regulatory elements (NREs) to mediate transcriptional repression of certain NK-kappa-B-responsive genes.

The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186416Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044149Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nourbakhsh M, Hauser H (Jan 2000). "Constitutive silencing of IFN-beta promoter is mediated by NRF (NF-kappaB-repressing factor), a nuclear inhibitor of NF-kappaB". EMBO J. 18 (22): 6415–25. doi:10.1093/emboj/18.22.6415. PMC 1171704. PMID 10562553.
  6. ^ a b "Entrez Gene: NKRF NF-kappaB repressing factor".

Further reading