DPP8

DPP8
Identifiers
Aliases	DPP8, DP8, DPRP1, MSTP141, MST097, MSTP097, MSTP135, DPRP-1, dipeptidyl peptidase 8
External IDs	OMIM: 606819; MGI: 1921638; HomoloGene: 57098; GeneCards: DPP8; OMA:DPP8 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	65,517,704 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	64,989,933 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; secondary oocyte; ; nipple; ; middle temporal gyrus; ; pons; ; postcentral gyrus; ; Skeletal muscle tissue of rectus abdominis; ; lateral nuclear group of thalamus; ; Brodmann area 23; ; biceps brachii;
	Top expressed in
	spermatocyte; ; muscle of thigh; ; superior frontal gyrus; ; aortic valve; ; cerebellar cortex; ; dentate gyrus of hippocampal formation granule cell; ; ascending aorta; ; temporal muscle; ; inferior colliculi; ; perirhinal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; aminopeptidase activity; dipeptidyl-peptidase activity; hydrolase activity;
Cellular component	cytoplasm; cytosol;
Biological process	immune response; proteolysis; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	54878
	74388
	ENSG00000074603
	ENSMUSG00000032393
	Q6V1X1
	Q80YA7
NM_017743; NM_130434; NM_197960; NM_197961; NM_001320875;
	NM_001320876
	NM_028906; NM_001401136
NP_001307804; NP_001307805; NP_060213; NP_569118; NP_932064;
	NP_932065; NP_932064.1; NP_001307804.1
	NP_083182; NP_001388065
	Wikidata
View/Edit Human	View/Edit Mouse

Dipeptidyl peptidase 8 is an enzyme that in humans is encoded by the DPP8 gene.^[5]^[6]

This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with Dipeptidyl peptidase-4 in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described.^[6]

References

Notes

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000074603 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032393 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Abbott CA, Yu DM, Woollatt E, Sutherland GR, McCaughan GW, Gorrell MD (Nov 2000). "Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8". Eur J Biochem. 267 (20): 6140–50. doi:10.1046/j.1432-1327.2000.01617.x. PMID 11012666.
^ ^a ^b "Entrez Gene: DPP8 dipeptidyl-peptidase 8".

Further reading

Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Ajami K; Abbott CA; Obradovic M; et al. (2003). "Structural requirements for catalysis, expression, and dimerization in the CD26/DPIV gene family". Biochemistry. 42 (3): 694–701. doi:10.1021/bi026846s. PMID 12534281. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Qi SY; Riviere PJ; Trojnar J; et al. (2003). "Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases". Biochem. J. 373 (Pt 1): 179–89. doi:10.1042/BJ20021914. PMC 1223468. PMID 12662155. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Shu H; Chen S; Bi Q; et al. (2004). "Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line". Mol. Cell. Proteomics. 3 (3): 279–86. doi:10.1074/mcp.D300003-MCP200. PMID 14729942. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Chen YS; Chien CH; Goparaju CM; et al. (2004). "Purification and characterization of human prolyl dipeptidase DPP8 in Sf9 insect cells". Protein Expr. Purif. 35 (1): 142–6. doi:10.1016/j.pep.2003.12.019. PMID 15039077. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Jiaang WT; Chen YS; Hsu T; et al. (2005). "Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8". Bioorg. Med. Chem. Lett. 15 (3): 687–91. doi:10.1016/j.bmcl.2004.11.023. PMID 15664838. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Ogasawara W; Tanaka C; Suzuki M; et al. (2005). "Isoforms of dipeptidyl aminopeptidase IV from Pseudomonas sp. WO24: role of the signal sequence and overexpression in Escherichia coli". Protein Expr. Purif. 41 (2): 241–51. doi:10.1016/j.pep.2004.10.027. PMID 15866709. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Kimura K; Wakamatsu A; Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Yu DM; Wang XM; Ajami K; et al. (2006). DP8 and DP9 have extra-enzymatic roles in cell adhesion, migration and apoptosis. Advances in Experimental Medicine and Biology. Vol. 575. pp. 63–72. doi:10.1007/0-387-32824-6_7. ISBN 978-0-387-29058-4. PMID 16700509. {{cite book}}: |journal= ignored (help); Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Yu DM, Wang XM, McCaughan GW, Gorrell MD (2006). "Extraenzymatic functions of the dipeptidyl peptidase IV-related proteins DP8 and DP9 in cell adhesion, migration and apoptosis". FEBS J. 273 (11): 2447–60. doi:10.1111/j.1742-4658.2006.05253.x. PMID 16704418.
Lee HJ; Chen YS; Chou CY; et al. (2007). "Investigation of the dimer interface and substrate specificity of prolyl dipeptidase DPP8". J. Biol. Chem. 281 (50): 38653–62. doi:10.1074/jbc.M603895200. PMID 17040910. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000074603 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032393 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11012666-5] Abbott CA, Yu DM, Woollatt E, Sutherland GR, McCaughan GW, Gorrell MD (Nov 2000). "Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8". Eur J Biochem. 267 (20): 6140–50. doi:10.1046/j.1432-1327.2000.01617.x. PMID 11012666.

[entrez-6] "Entrez Gene: DPP8 dipeptidyl-peptidase 8".

[1]

[2]

[3]

[4]

[5]

[6]