CDIPT

CDIPT
Identifiers
Aliases	CDIPT, PIS, PIS1, CDP-diacylglycerol--inositol 3-phosphatidyltransferase
External IDs	OMIM: 605893; MGI: 105491; HomoloGene: 7159; GeneCards: CDIPT; OMA:CDIPT - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	29,863,414 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	126,579,673 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; endothelial cell; ; Brodmann area 23; ; sperm; ; middle temporal gyrus; ; pancreatic ductal cell; ; germinal epithelium; ; visceral pleura; ; parietal pleura; ; gingival epithelium;
	Top expressed in
	Paneth cell; ; motor neuron; ; substantia nigra; ; retinal pigment epithelium; ; barrel cortex; ; seminal vesicula; ; endocardial cushion; ; fossa; ; facial motor nucleus; ; medullary collecting duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; phosphotransferase activity, for other substituted phosphate groups; manganese ion binding; alcohol binding; CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity; protein binding; diacylglycerol binding; carbohydrate binding;
Cellular component	integral component of membrane; Golgi apparatus; endoplasmic reticulum membrane; membrane; Golgi membrane; plasma membrane; endoplasmic reticulum;
Biological process	lipid metabolism; CDP-diacylglycerol metabolic process; phospholipid biosynthetic process; phosphatidylinositol biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	10423
	52858
	ENSG00000103502
	ENSMUSG00000030682
	O14735
	Q8VDP6
	NM_001286585; NM_001286586; NM_006319; NM_145752
	NM_026638; NM_001347656; NM_001379260
NP_001273514; NP_001273515; NP_006310; NP_001273514.1; NP_001273515.1;
	NP_006310.1
	NP_001334585; NP_080914; NP_001366189
	Wikidata
View/Edit Human	View/Edit Mouse

CDP-diacylglycerol—inositol 3-phosphatidyltransferase is an enzyme that in humans is encoded by the CDIPT gene.^[5]^[6]

Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of multiple G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103502 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030682 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lykidis A, Jackson PD, Rock CO, Jackowski S (Jan 1998). "The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content". J Biol Chem. 272 (52): 33402–9. doi:10.1074/jbc.272.52.33402. PMID 9407135.
^ ^a ^b "Entrez Gene: CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)".

External links

Human CDIPT genome location and CDIPT gene details page in the UCSC Genome Browser.

Antonsson B (1997). "Phosphatidylinositol synthase from mammalian tissues". Biochim. Biophys. Acta. 1348 (1–2): 179–86. doi:10.1016/s0005-2760(97)00105-7. PMID 9370331.
Antonsson BE (1994). "Purification and characterization of phosphatidylinositol synthase from human placenta". Biochem. J. 297 (Pt 3): 517–22. PMC 1137864. PMID 8110188.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y; Yoshitomo-Nakagawa K; Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Bouwmeester T; Bauch A; Ruffner H; et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
de Serres FJ; Luisetti M; Ferrarotti I; et al. (2005). "Alpha-1 antitrypsin deficiency in Italy: regional differences of the PIS and PIZ deficiency alleles". Monaldi Archives for Chest Disease. 63 (3): 133–41. PMID 16312203. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000103502 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030682 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9407135-5] Lykidis A, Jackson PD, Rock CO, Jackowski S (Jan 1998). "The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content". J Biol Chem. 272 (52): 33402–9. doi:10.1074/jbc.272.52.33402. PMID 9407135.

[entrez-6] "Entrez Gene: CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)".

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[6]

References

External links

Further reading