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SFRP5

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SFRP5
Identifiers
AliasesSFRP5, SARP3, secreted frizzled related protein 5
External IDsOMIM: 604158; MGI: 1860298; HomoloGene: 2268; GeneCards: SFRP5; OMA:SFRP5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003015

NM_018780

RefSeq (protein)

NP_003006

NP_061250

Location (UCSC)Chr 10: 97.77 – 97.77 MbChr 19: 42.19 – 42.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Secreted frizzled-related protein 5 is a protein that in humans is encoded by the SFRP5 gene.[5][6]

Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120057Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018822Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Melkonyan HS, Chang WC, Shapiro JP, Mahadevappa M, Fitzpatrick PA, Kiefer MC, Tomei LD, Umansky SR (Jan 1998). "SARPs: A family of secreted apoptosis-related proteins". Proc Natl Acad Sci U S A. 94 (25): 13636–41. doi:10.1073/pnas.94.25.13636. PMC 28358. PMID 9391078.
  6. ^ a b "Entrez Gene: SFRP5 secreted frizzled-related protein 5".

Further reading